Document Detail

Suppression of feeding-evoked dopamine release in the rat nucleus accumbens by the blockade of P(2) purinoceptors.
MedLine Citation:
PMID:  11040358     Owner:  NLM     Status:  MEDLINE    
In order to investigate whether endogenous adenosine 5'-triphosphate (ATP) is involved in the regulation of feeding, the influence of the P(2) receptor antagonist pyridoxalphospate-6-azophenyl-2', 4'-disulphonic acid (PPADS) infused into the rat nucleus accumbens on 18-h food-deprived feeding was tested. PPADS suppressed the feeding-induced dopamine release and reduced the amount of food consumed as well as the time of feeding. These results indicate that activation of P(2) purinoceptors by endogenous ATP facilitates feeding behaviour and contributes to the feeding-associated dopamine release.
H Kittner; U Krügel; I M El-Ashmawy; P Illes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  406     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-12-11     Completed Date:  2000-12-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  R13-4     Citation Subset:  IM    
Rudolf-Boehm-Department of Pharmacology and Toxicology, Universität Leipzig, Härtelstrasse 16-18, D-04107, Leipzig, Germany.
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MeSH Terms
Adenosine Triphosphate / physiology
Dopamine / secretion*
Nucleus Accumbens / drug effects,  secretion*
Pyridoxal Phosphate / analogs & derivatives*,  pharmacology
Rats, Wistar
Receptors, Purinergic P2 / antagonists & inhibitors,  physiology*
Reg. No./Substance:
0/Receptors, Purinergic P2; 149017-66-3/pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid; 54-47-7/Pyridoxal Phosphate; 56-65-5/Adenosine Triphosphate

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