Document Detail


Suppression of feeding-evoked dopamine release in the rat nucleus accumbens by the blockade of P(2) purinoceptors.
MedLine Citation:
PMID:  11040358     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to investigate whether endogenous adenosine 5'-triphosphate (ATP) is involved in the regulation of feeding, the influence of the P(2) receptor antagonist pyridoxalphospate-6-azophenyl-2', 4'-disulphonic acid (PPADS) infused into the rat nucleus accumbens on 18-h food-deprived feeding was tested. PPADS suppressed the feeding-induced dopamine release and reduced the amount of food consumed as well as the time of feeding. These results indicate that activation of P(2) purinoceptors by endogenous ATP facilitates feeding behaviour and contributes to the feeding-associated dopamine release.
Authors:
H Kittner; U Krügel; I M El-Ashmawy; P Illes
Related Documents :
14511138 - The nutrition of the chinchilla as a companion animal--basic data, influences and depen...
7290308 - Brain damage in mice from voluntary ingestion of glutamate and aspartate.
7979338 - Effect of changing daylength on the diurnal pattern of intake and feeding behaviour in ...
18328408 - Safety and nutritional assessment of gm plants and derived food and feed: the role of a...
24345328 - Evaluating the effectiveness of fish consumption advisories: modeling prenatal, postnat...
7143268 - The nutritional values and food group characteristics of foods preferred during various...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  406     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-12-11     Completed Date:  2000-12-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  R13-4     Citation Subset:  IM    
Affiliation:
Rudolf-Boehm-Department of Pharmacology and Toxicology, Universität Leipzig, Härtelstrasse 16-18, D-04107, Leipzig, Germany. kith@medizin.uni-leipzig.de
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / physiology
Animals
Dopamine / secretion*
Eating*
Male
Nucleus Accumbens / drug effects,  secretion*
Pyridoxal Phosphate / analogs & derivatives*,  pharmacology
Rats
Rats, Wistar
Receptors, Purinergic P2 / antagonists & inhibitors,  physiology*
Chemical
Reg. No./Substance:
0/Receptors, Purinergic P2; 149017-66-3/pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid; 54-47-7/Pyridoxal Phosphate; 56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Energy-dependent UV light-induced disruption of (-)sulpiride antagonism of dopamine.
Next Document:  A system for the study of visuomotor coordination during reaching for moving targets.