Document Detail

Suppression of fatty acids synthesis in brown adipose tissue of mice fed diets rich in long chain fatty acids.
MedLine Citation:
PMID:  7295753     Owner:  NLM     Status:  MEDLINE    
The influence of dietary lipid on fatty acid synthesis in brown adipose tissue has been investigated by feeding different high-fat diets to cold-acclimated mice for a period of 2 weeks. Fatty acid synthesis was measured in vivo with 3H2O, and the fats used in the study were maize oil, beef tallow and medium chain triacylglycerol oil. In the mice fed the maize oil and the beef tallow diets fatty acids synthesis was inhibited in all tissue examined--interscapular brown adipose tissue, epididymal white adipose tissue, the liver and the carcass. Synthesis was more inhibited, however, in brown adipose tissue than in other tissues, and the inhibition was greater on the maize oil diet than on the beef tallow. The medium chain triacylglycerol oil had no inhibitory effect on fatty acid synthesis in any tissue, and hepatic synthesis was even elevated on this diet. It is concluded that fatty acid synthesis in brown adipose tissue, as in other lipogenic tissues, is subject to strong suppression by dietary long chain fatty acids, and particularly by linoleic acid.
P A Van den Brandt; P Trayhurn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  665     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1982-01-20     Completed Date:  1982-01-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  602-7     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue, Brown / drug effects,  metabolism*
Cold Temperature
Dietary Fats / pharmacology*
Energy Intake
Fatty Acids / biosynthesis*,  pharmacology
Liver / metabolism
Mice, Inbred C57BL
Structure-Activity Relationship
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids

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