Document Detail

Suppression of an established immune response by UVA--a critical role for mast cells.
MedLine Citation:
PMID:  17880504     Owner:  NLM     Status:  MEDLINE    
Exposing experimental animals or human volunteers to UVA II (320-340 nm) radiation after immunization suppresses immunologic memory and the elicitation of delayed-in-time hypersensitivity reactions. Previous studies indicated that the mechanisms underlying UVA-induced immune suppression are similar to those described for UVB-induced immune suppression, i.e. transferred by T regulatory cells, overcome by repairing DNA damage, neutralizing interleukin (IL)-10 activity, or injecting recombinant IL-12. Here we continued our examination of the mechanisms involved in UVA II-induced suppression. Antibodies to cis-urocanic acid blocked UVA-induced immune suppression. Treating UVA-irradiated mice with histamine receptor antagonists, calcitonin gene-related peptide (CGRP) receptor antagonists or platelet activating factor receptor antagonists blocked immune suppression in UVA-irradiated mice. In light of the fact that cis-urocanic acid and CGRP target mast cells, which can then release platelet activating factor and histamine, we measured UVA-induced immune suppression in mast cell-deficient mice. No immune suppression was noted in UVA-irradiated mast cell-deficient mice. These findings indicate that exposure to UVA II activates many of the same immune regulatory factors activated by UVB to induce immune suppression. Moreover, they indicate that mast cells play a critical role in UVA-induced suppression of secondary immune reactions.
Stephen E Ullrich; Dat X Nghiem; Polina Khaskina
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Photochemistry and photobiology     Volume:  83     ISSN:  0031-8655     ISO Abbreviation:  Photochem. Photobiol.     Publication Date:    2007 Sep-Oct
Date Detail:
Created Date:  2007-09-20     Completed Date:  2008-01-07     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0376425     Medline TA:  Photochem Photobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1095-100     Citation Subset:  IM    
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MeSH Terms
Calcitonin Gene-Related Peptide / physiology
Histamine H1 Antagonists / pharmacology
Mast Cells / immunology,  radiation effects*
Mice, Inbred C3H
Mice, Inbred C57BL
Platelet Membrane Glycoproteins / antagonists & inhibitors
Receptors, G-Protein-Coupled / antagonists & inhibitors
Ultraviolet Rays*
Grant Support
CA112660/CA/NCI NIH HHS; CA16672/CA/NCI NIH HHS; CA75575/CA/NCI NIH HHS; P30 CA016672-22S29012/CA/NCI NIH HHS; R01 CA075575/CA/NCI NIH HHS; R01 CA075575-12/CA/NCI NIH HHS; R01 CA112660/CA/NCI NIH HHS; R01 CA112660-03/CA/NCI NIH HHS
Reg. No./Substance:
0/Histamine H1 Antagonists; 0/Platelet Membrane Glycoproteins; 0/Receptors, G-Protein-Coupled; 0/platelet activating factor receptor; 83652-28-2/Calcitonin Gene-Related Peptide

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