| Suppression of erythroid cell differentiation in mouse embryos exposed to retinoic acid in utero. | |
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MedLine Citation:
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PMID: 2464957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Differentiation of circulating erythrocytes was inhibited by all-trans-retinoic acid in 8- and 9-day-old mouse embryos exposed in utero on day 8 of gestation. Histochemical, light, and electron microscopic examinations revealed that all-trans-retinoic acid first decreased the numbers of polychromatic erythroblasts and then increased them. Simultaneously, immature erythroblasts proliferated, and differentiation of mature primitive erythrocytes was suppressed. Electron microscopy of these immature erythroblasts revealed monosomes rather than the usual polyribosomes in the cytoplasm. RNA histochemistry revealed a greater number of intermediate differentiating erythroblasts with pyronin-positive cytoplasm than those in the controls and revealed also a dose-dependent relationship between the number of polychromatic erythroblasts with positive pyronin staining and the controls. These findings suggest that all-trans-retinoic acid destroys the messenger RNA system, resulting in an inability to produce hemoglobin. |
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Authors:
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Y Yasuda; H Konishi; T Matsuo; T Tanimura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Anatomical record Volume: 223 ISSN: 0003-276X ISO Abbreviation: Anat. Rec. Publication Date: 1989 Jan |
Date Detail:
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Created Date: 1989-03-23 Completed Date: 1989-03-23 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370540 Medline TA: Anat Rec Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-12 Citation Subset: IM |
Affiliation:
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Department of Anatomy (1st Division), Kinki University School of Medicine, Osaka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / drug effects Cell Division / drug effects Erythrocytes / cytology*, drug effects, ultrastructure Erythropoiesis / drug effects Female Histocytochemistry Male Mice Mice, Inbred ICR Microscopy, Electron RNA / metabolism Tretinoin / pharmacology* Yolk Sac / cytology |
| Chemical | |
Reg. No./Substance:
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302-79-4/Tretinoin; 63231-63-0/RNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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