Document Detail

Suppression of drinking but not feeding by central eledoisin and physalaemin in the rat.
MedLine Citation:
PMID:  3963799     Owner:  NLM     Status:  MEDLINE    
The tachykinins, eledoisin and physalaemin, given by intracerebroventricular (i.c.v.) injection have been shown to be potent antidipsogenic agents in rats. To evaluate their selectivity of action on rat ingestive behaviors, we compared their effects following i.c.v. injection on the intake of water, of milk containing 3.5 or 15% fat, and of solid food. The two tachykinins inhibited water intake induced by i.c.v. angiotensin II or by cellular dehydration, but did not reduce the intake of 15% fat milk or of solid food. The intake of 3.5% fat milk was inhibited only by the highest dose (1000 ng/rat) of eledoisin which also increased grooming and locomotion. The present findings suggest that in adult rats central eledoisin and physalaemin exert a selective suppressive effect on drinking behavior without affecting feeding.
M Massi; L G Micossi; G de Caro; A N Epstein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Appetite     Volume:  7     ISSN:  0195-6663     ISO Abbreviation:  Appetite     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-05-02     Completed Date:  1986-05-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8006808     Medline TA:  Appetite     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  63-70     Citation Subset:  IM    
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MeSH Terms
Drinking / drug effects*
Eating / drug effects*
Eledoisin / administration & dosage,  pharmacology*
Injections, Intraventricular
Kinins / pharmacology*
Physalaemin / administration & dosage,  pharmacology*
Rats, Inbred Strains
Grant Support
Reg. No./Substance:
0/Kinins; 2507-24-6/Physalaemin; 69-25-0/Eledoisin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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