Document Detail


Suppression of dibutylnitrosamine-induced bladder carcinomas in hamsters by dietary indole.
MedLine Citation:
PMID:  864759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effect of dietary indole on the urinary bladder tumorigenesis by chronic dibutylnitrosamine (DBN) treatment was evaluated in hamsters. In the first experiment, in which DBN-water and diet were given ad libitum, dietary indole significantly suppressed bladder tumor incidence. The inhibitory effect was more pronounced in males. In the second experiment, in which consumption of both diet and DBN-water was rigidly controlled by pair-feeding, dietary indole again significantly suppressed bladder tumor incidence; its effect was similar in both males and females. This suppressive effect of indole on bladder tumorigenesis contrasted markedly with its failure to suppress tumors at other sites such as nasal sinuses, trachea, esophagus, and fore-stomach.
Authors:
M Matsumoto; R Oyasu; M L Hopp; T Kitajima
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the National Cancer Institute     Volume:  58     ISSN:  0027-8874     ISO Abbreviation:  J. Natl. Cancer Inst.     Publication Date:  1977 Jun 
Date Detail:
Created Date:  1977-07-29     Completed Date:  1977-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503089     Medline TA:  J Natl Cancer Inst     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1825-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Body Weight / drug effects
Cricetinae
Female
Indoles / administration & dosage,  pharmacology*
Male
Neoplasms, Experimental / chemically induced,  urine
Nitrosamines / antagonists & inhibitors*,  urine
Urinary Bladder Neoplasms / chemically induced*,  urine
Chemical
Reg. No./Substance:
0/Indoles; 0/Nitrosamines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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