Document Detail

Suppression of dibutylnitrosamine-induced bladder carcinomas in hamsters by dietary indole.
MedLine Citation:
PMID:  864759     Owner:  NLM     Status:  MEDLINE    
Effect of dietary indole on the urinary bladder tumorigenesis by chronic dibutylnitrosamine (DBN) treatment was evaluated in hamsters. In the first experiment, in which DBN-water and diet were given ad libitum, dietary indole significantly suppressed bladder tumor incidence. The inhibitory effect was more pronounced in males. In the second experiment, in which consumption of both diet and DBN-water was rigidly controlled by pair-feeding, dietary indole again significantly suppressed bladder tumor incidence; its effect was similar in both males and females. This suppressive effect of indole on bladder tumorigenesis contrasted markedly with its failure to suppress tumors at other sites such as nasal sinuses, trachea, esophagus, and fore-stomach.
M Matsumoto; R Oyasu; M L Hopp; T Kitajima
Related Documents :
2294519 - Calorie consumption level influences development of c3h/ou breast adenocarcinoma with i...
1192409 - Animal models for the study of dietary factors and cancer of the large bowel.
24049619 - Effects of pure eicosapentaenoic and docosahexaenoic acids on oxidative stress, inflamm...
9314049 - Assessment of chronic toxicity and carcinogenicity in rats of wingstay 100, a rubber an...
9682249 - Dietary lipids alter fatty acid composition and pge2 production in colonic lymphocytes.
988189 - Effect of a diet with high levels of protein and fat on colon carcinogenesis in f344 ra...
1129769 - Sex-difference in the response to different kinds of dietary carbohydrates in rats.
25367279 - Intake, performance, and efficiency of nutrient utilization in saanen goat kids fed die...
7378339 - Energy and protein nutrition of early-weaned pigs. 2. effect of energy intake and energ...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the National Cancer Institute     Volume:  58     ISSN:  0027-8874     ISO Abbreviation:  J. Natl. Cancer Inst.     Publication Date:  1977 Jun 
Date Detail:
Created Date:  1977-07-29     Completed Date:  1977-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503089     Medline TA:  J Natl Cancer Inst     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1825-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Oral
Body Weight / drug effects
Indoles / administration & dosage,  pharmacology*
Neoplasms, Experimental / chemically induced,  urine
Nitrosamines / antagonists & inhibitors*,  urine
Urinary Bladder Neoplasms / chemically induced*,  urine
Reg. No./Substance:
0/Indoles; 0/Nitrosamines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Immune response to L2 guinea pig leukemia-specific antigens.
Next Document:  Cocarcinogenic interaction between D,L-tryptophan and 4-aminobiphenyl or 2-naphthylamine in dogs.