| Suppression of cytochrome P450 1A1 expression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mouse hepatoma hepa-1c1c7 cells treated with serum of (-)-epigallocatechin-3-gallate- and green tea extract-administered rats. | |
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MedLine Citation:
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PMID: 19420696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The suppression of cytochrome P450 1A1 (CYP1A1) expression was examined in mouse hepatoma Hepa-1c1c7 cells treated with serum prepared from (-)-epigallocatechin-3-gallate- and green tea extract-administered rats. Catechins were found in the rat plasma after the administration. In Hepa-1c1c7 cells, 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 expression was suppressed by treatment with the rat serum. It is concluded that catechins can possibly modulate CYP1A1 expression. |
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Authors:
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Itsuko Fukuda; Miki Tsutsui; Iwao Sakane; Hitoshi Ashida |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-07 |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: 73 ISSN: 1347-6947 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-25 Completed Date: 2009-08-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: Japan |
Other Details:
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Languages: eng Pagination: 1206-8 Citation Subset: IM |
Affiliation:
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Research Center for Food Safety and Security, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo, Japan. itsuko@silver.kobe-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Hepatocellular / genetics, pathology* Catechin / administration & dosage, analogs & derivatives*, blood, pharmacology Cell Line, Tumor Cytochrome P-450 CYP1A1 / metabolism* Down-Regulation / drug effects Gene Expression Regulation, Neoplastic / drug effects* Male Mice Plant Extracts / administration & dosage, blood, pharmacology* Rats Tea / chemistry* Tetrachlorodibenzodioxin / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Plant Extracts; 0/Tea; 154-23-4/Catechin; 1746-01-6/Tetrachlorodibenzodioxin; 989-51-5/epigallocatechin gallate; EC 1.14.14.1/Cytochrome P-450 CYP1A1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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