Document Detail

Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes.
MedLine Citation:
PMID:  9233639     Owner:  NLM     Status:  MEDLINE    
Con A-induced hepatitis (Con A-hepatitis) is a hepatitis model in which hepatic injury is supposed to be caused by cytokines from activated T cells. To elucidate the pathogenesis of this disease, we analyzed the roles of IFN-gamma and TNF-alpha using deficient mice of these cytokines. Development of hepatitis was reduced significantly in IFN-gamma(-/-) mice, while susceptibility of TNF-alpha(-/-) mice was not changed. Interestingly, apoptotic cell death was observed in the affected livers of control or TNF-alpha(-/-) mice, but not in those of IFN-gamma(-/-) mice. Fas mRNA expression was increased in the livers of hepatitis mice, but less abundantly in those of IFN-gamma(-/-) mice. Since apoptosis of liver cells was rarely observed in Con A-treated lpr/lpr mice, involvement of the Fas-Fas ligand system in this apoptotic process was suggested. These observations suggest that IFN-gamma plays a central role in Con A-hepatitis by activating Fas-induced apoptosis of liver cells.
Y Tagawa; K Sekikawa; Y Iwakura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  159     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-08-14     Completed Date:  1997-08-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1418-28     Citation Subset:  AIM; IM    
Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Japan.
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MeSH Terms
Antigens, CD95 / physiology
Apoptosis / drug effects,  genetics,  immunology*
Chimera / immunology
Concanavalin A / toxicity*
Gene Expression Regulation / immunology
Genetic Engineering
Hepatitis, Animal / genetics*,  immunology*,  pathology
Immune Tolerance / drug effects,  genetics*
Interferon-gamma / biosynthesis,  deficiency*,  physiology*
Liver / drug effects,  immunology*,  metabolism
Mice, Inbred C57BL
Mice, Knockout
Plant Lectins
Tumor Necrosis Factor-alpha / deficiency*,  genetics
Reg. No./Substance:
0/Antigens, CD95; 0/Plant Lectins; 0/Tumor Necrosis Factor-alpha; 11028-71-0/Concanavalin A; 82115-62-6/Interferon-gamma

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