Document Detail

Suppression of cesium-induced ventricular tachyarrhythmias by atrial natriuretic peptide in rabbits.
MedLine Citation:
PMID:  10997752     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Intravenous injection of cesium chloride (Cs) causes ventricular tachyarrhythmias in rabbits. We investigated whether these tachyarrhythmias were caused by increased pressure load and whether they could be suppressed by atrial natriuretic peptide (ANP). METHODS AND RESULTS: Cs was injected in a bolus dose (1.5 mmol/kg), which was repeated 20 minutes later. Rabbits were then divided into 3 groups: control, ANP-treated, and hydralazine-treated groups. ANP or hydralazine was administered between the first and second Cs injections. The experiments were performed during intrinsic sinus rhythm (protocol A) or during ventricular pacing (protocol B). In protocol A, the second injection of Cs in the control group induced early afterdepolarizations and ventricular tachycardia, which were preceded by a marked increase in left ventricular end-diastolic pressure (LVEDP). Both ANP and hydralazine significantly suppressed Cs-induced increase in LVEDP. The arrhythmia score after the second injection of Cs was significantly lower in the ANP-treated and hydralazine-treated group compared with the control group (P < .005 and P < .05, respectively). In protocol B, the duration of left ventricular monophasic action potential and early afterdepolarization amplitude before and/or after the injections of Cs did not differ significantly between control and ANP-treated groups. CONCLUSIONS: Our results suggest that increased pressure load may play a role in the arrhythmogenic effect of Cs. The protective effect of ANP against Cs-induced ventricular tachycardia may be explained in part by a reduction in pressure overload. However, this effect might also be explained by the diverse action of ANP on the cardiovascular system.
T Ooie; N Takahashi; T Saikawa; T Iwao; M Hara; T Sakata
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiac failure     Volume:  6     ISSN:  1071-9164     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2001-01-09     Completed Date:  2001-01-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  250-6     Citation Subset:  IM    
Department of Internal Medicine I, School of Medicine, Oita Medical University, Hasama, Japan.
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MeSH Terms
Action Potentials
Anti-Arrhythmia Agents / administration & dosage,  metabolism*,  pharmacology
Antihypertensive Agents / administration & dosage,  pharmacology*
Atrial Natriuretic Factor / administration & dosage,  metabolism*,  pharmacology
Blood Pressure / drug effects*
Cesium / adverse effects,  antagonists & inhibitors*
Chlorides / adverse effects,  antagonists & inhibitors*
Diastole / drug effects
Hydralazine / pharmacology
Tachycardia, Ventricular / chemically induced,  metabolism*
Vasodilator Agents / pharmacology
Ventricular Function, Left / drug effects*
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Antihypertensive Agents; 0/Chlorides; 0/Vasodilator Agents; 7440-46-2/Cesium; 7647-17-8/cesium chloride; 85637-73-6/Atrial Natriuretic Factor; 86-54-4/Hydralazine

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