| Suppression of c-Jun/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells. | |
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MedLine Citation:
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PMID: 1905019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Curcumin, a dietary pigment responsible for the yellow color of curry, is a potent inhibitor of tumor promotion by phorbol esters. Functional activation of transcriptional factor c-Jun/AP-1 is believed to play an important role in signal transduction of phorbol 12-myristate 13-acetate-induced tumor promotion. Suppression of the c-Jun/AP-1 activation by curcumin is observed in mouse fibroblast cells. In vitro experiments indicate that inhibition of c-Jun/AP-1 binding to its cognate motif by curcumin may be responsible for the inhibition of c-Jun/AP-1-mediated gene expression. These findings show that the effect of curcumin on phorbol 12-myristate 13-acetate-induced inflammation/tumor promotion could be studied at the molecular level. |
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Authors:
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T S Huang; S C Lee; J K Lin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 88 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1991 Jun |
Date Detail:
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Created Date: 1991-07-19 Completed Date: 1991-07-19 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 5292-6 Citation Subset: IM |
Affiliation:
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Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, R.O.C. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Blotting, Northern Carcinogens* Cells, Cultured Curcumin / pharmacology* DNA-Binding Proteins / antagonists & inhibitors* Fibroblasts / drug effects, metabolism Mice Molecular Sequence Data Nucleic Acid Hybridization Proto-Oncogene Proteins / antagonists & inhibitors*, genetics Proto-Oncogene Proteins c-fos Proto-Oncogene Proteins c-jun RNA, Messenger / analysis Regulatory Sequences, Nucleic Acid Tetradecanoylphorbol Acetate / toxicity* Transcription Factors / antagonists & inhibitors* Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/DNA-Binding Proteins; 0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 0/RNA, Messenger; 0/Transcription Factors; 16561-29-8/Tetradecanoylphorbol Acetate; 458-37-7/Curcumin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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