Document Detail


Suppression of c-Jun/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells.
MedLine Citation:
PMID:  1905019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Curcumin, a dietary pigment responsible for the yellow color of curry, is a potent inhibitor of tumor promotion by phorbol esters. Functional activation of transcriptional factor c-Jun/AP-1 is believed to play an important role in signal transduction of phorbol 12-myristate 13-acetate-induced tumor promotion. Suppression of the c-Jun/AP-1 activation by curcumin is observed in mouse fibroblast cells. In vitro experiments indicate that inhibition of c-Jun/AP-1 binding to its cognate motif by curcumin may be responsible for the inhibition of c-Jun/AP-1-mediated gene expression. These findings show that the effect of curcumin on phorbol 12-myristate 13-acetate-induced inflammation/tumor promotion could be studied at the molecular level.
Authors:
T S Huang; S C Lee; J K Lin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  88     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-07-19     Completed Date:  1991-07-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  5292-6     Citation Subset:  IM    
Affiliation:
Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, R.O.C.
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MeSH Terms
Descriptor/Qualifier:
Animals
Base Sequence
Blotting, Northern
Carcinogens*
Cells, Cultured
Curcumin / pharmacology*
DNA-Binding Proteins / antagonists & inhibitors*
Fibroblasts / drug effects,  metabolism
Mice
Molecular Sequence Data
Nucleic Acid Hybridization
Proto-Oncogene Proteins / antagonists & inhibitors*,  genetics
Proto-Oncogene Proteins c-fos
Proto-Oncogene Proteins c-jun
RNA, Messenger / analysis
Regulatory Sequences, Nucleic Acid
Tetradecanoylphorbol Acetate / toxicity*
Transcription Factors / antagonists & inhibitors*
Transcription, Genetic
Chemical
Reg. No./Substance:
0/Carcinogens; 0/DNA-Binding Proteins; 0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 0/RNA, Messenger; 0/Transcription Factors; 16561-29-8/Tetradecanoylphorbol Acetate; 458-37-7/Curcumin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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