| Suppression of blood glucose level by a new fermented tea obtained by tea-rolling processing of loquat (Eriobotrya japonica) and green tea leaves in disaccharide-loaded Sprague-Dawley rats. | |
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MedLine Citation:
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PMID: 20355112 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In the field of food science, much interest has been focused on the development of alternative medicinal foods with the ability to regulate excess blood glucose level (BGL) rise. The authors have successfully developed a new fermented tea product (LG tea) by co-fermentation of loquat (Eriobotrya japonica) leaf and summer-harvested green tea leaf. The objective of this study was to examine the acute suppression effect of LG tea on BGL rise in disaccharide-loaded Sprague-Dawley (SD) rats and to evaluate its possible usage as an antidiabetic functional food material. RESULTS: As a result of single oral administration of hot water extract of LG tea (50 mg kg(-1)) to maltose-loaded SD rats, BGL at 30 min was significantly decreased by 23.8% (P < 0.01) compared with the control. A corresponding reduction in serum insulin secretion was also observed. The ED(50) value of LG tea (50.7 mg kg(-1)) was estimated to be about 16-fold higher than that of the therapeutic drug acarbose (3.1 mg kg(-1)). CONCLUSION: No significant change in BGL was observed when sucrose or glucose was administered, suggesting that the suppression effect of LG tea was achieved by maltase inhibition, not by sucrase inhibition or glucose transport inhibition at the intestinal membrane. |
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Authors:
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Kei Tamaya; Toshiro Matsui; Asami Toshima; Mai Noguchi; Qiu Ju; Yuji Miyata; Takashi Tanaka; Kazunari Tanaka |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the science of food and agriculture Volume: 90 ISSN: 1097-0010 ISO Abbreviation: J. Sci. Food Agric. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-31 Completed Date: 2010-06-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376334 Medline TA: J Sci Food Agric Country: England |
Other Details:
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Languages: eng Pagination: 779-83 Citation Subset: IM |
Copyright Information:
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(c) 2010 Society of Chemical Industry. |
Affiliation:
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Industrial Technology Center of Nagasaki, Ohmura, Nagasaki 856-0026, Japan. tamaya@tc.nagasaki.go.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Beverages* Blood Glucose / analysis* Diabetes Mellitus, Type 2 / diet therapy Eriobotrya* Fermentation* Food Handling Functional Food Glucose Tolerance Test Hyperglycemia / prevention & control Insulin / blood Male Maltose / administration & dosage* Plant Leaves* Postprandial Period Rats Rats, Sprague-Dawley Sucrose / administration & dosage Tea* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Tea; 11061-68-0/Insulin; 57-50-1/Sucrose; 69-79-4/Maltose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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