Document Detail

Suppression of blood glucose level by a new fermented tea obtained by tea-rolling processing of loquat (Eriobotrya japonica) and green tea leaves in disaccharide-loaded Sprague-Dawley rats.
MedLine Citation:
PMID:  20355112     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In the field of food science, much interest has been focused on the development of alternative medicinal foods with the ability to regulate excess blood glucose level (BGL) rise. The authors have successfully developed a new fermented tea product (LG tea) by co-fermentation of loquat (Eriobotrya japonica) leaf and summer-harvested green tea leaf. The objective of this study was to examine the acute suppression effect of LG tea on BGL rise in disaccharide-loaded Sprague-Dawley (SD) rats and to evaluate its possible usage as an antidiabetic functional food material. RESULTS: As a result of single oral administration of hot water extract of LG tea (50 mg kg(-1)) to maltose-loaded SD rats, BGL at 30 min was significantly decreased by 23.8% (P < 0.01) compared with the control. A corresponding reduction in serum insulin secretion was also observed. The ED(50) value of LG tea (50.7 mg kg(-1)) was estimated to be about 16-fold higher than that of the therapeutic drug acarbose (3.1 mg kg(-1)). CONCLUSION: No significant change in BGL was observed when sucrose or glucose was administered, suggesting that the suppression effect of LG tea was achieved by maltase inhibition, not by sucrase inhibition or glucose transport inhibition at the intestinal membrane.
Kei Tamaya; Toshiro Matsui; Asami Toshima; Mai Noguchi; Qiu Ju; Yuji Miyata; Takashi Tanaka; Kazunari Tanaka
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the science of food and agriculture     Volume:  90     ISSN:  1097-0010     ISO Abbreviation:  J. Sci. Food Agric.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-31     Completed Date:  2010-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376334     Medline TA:  J Sci Food Agric     Country:  England    
Other Details:
Languages:  eng     Pagination:  779-83     Citation Subset:  IM    
Copyright Information:
(c) 2010 Society of Chemical Industry.
Industrial Technology Center of Nagasaki, Ohmura, Nagasaki 856-0026, Japan.
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MeSH Terms
Blood Glucose / analysis*
Diabetes Mellitus, Type 2 / diet therapy
Food Handling
Functional Food
Glucose Tolerance Test
Hyperglycemia / prevention & control
Insulin / blood
Maltose / administration & dosage*
Plant Leaves*
Postprandial Period
Rats, Sprague-Dawley
Sucrose / administration & dosage
Time Factors
Reg. No./Substance:
0/Blood Glucose; 0/Tea; 11061-68-0/Insulin; 57-50-1/Sucrose; 69-79-4/Maltose

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