| Suppression of basal plasma cortisol and adrenal androgen concentrations, but not of ACTH and cortisol responses to hCRH by low-dose dexamethasone in rhesus monkeys. | |
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MedLine Citation:
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PMID: 2838697 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glucocorticoid treatment at replacement doses does not result in a suppression of ACTH and cortisol responses to corticotropin-releasing hormone (CRH), while basal plasma concentrations of cortisol and adrenal androgens are efficiently suppressed 34 h after starting treatment. This finding could be demonstrated in rhesus monkeys receiving a continuous infusion of dexamethasone (1 microgram/kg per h) for 48 h and confirms our observations in patients on alternate-day prednisone therapy and in patients with congenital adrenal hyperplasia on glucocorticoid replacement therapy. We conclude that the decrease of basal adrenal steroid secretion resulting from glucocorticoid replacement therapy represents an effect on hypothalamic rather than on pituitary function. |
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Authors:
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T H Schürmeyer; B T Gallucci; T P Tomai |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of steroid biochemistry Volume: 30 ISSN: 0022-4731 ISO Abbreviation: J. Steroid Biochem. Publication Date: 1988 |
Date Detail:
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Created Date: 1988-08-11 Completed Date: 1988-08-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0260125 Medline TA: J Steroid Biochem Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 435-7 Citation Subset: IM |
Affiliation:
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Department of Clinical Endocrinology, Medizinische Hochschule Hannover, F.R.G. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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secretion* Androgens / blood, metabolism* Animals Corticotropin-Releasing Hormone / pharmacology* Dexamethasone / pharmacology* Dose-Response Relationship, Drug Hydrocortisone / blood*, secretion Kinetics Macaca mulatta Male Pituitary-Adrenal System / drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Androgens; 50-02-2/Dexamethasone; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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