Document Detail


Suppression at high spatial frequencies in the lateral geniculate nucleus of the cat.
MedLine Citation:
PMID:  17596414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The spatial weighting functions of both retinal and lateral geniculate nucleus (LGN) X-cell receptive fields have been viewed as the difference of two Gaussians (DOG). We focus on a particular shortcoming of the DOG model, that is, suppression of responses of LGN cells at spatial frequencies above those to which the classical receptive field surround is responsive. By simultaneously recording one of the retinal ganglion cell (RGC) inputs (S-potentials) to an LGN cell, we find that half of this suppression at high spatial frequencies arises from the retinal input and that suppression in LGN cells is greater than that in RGCs, regardless of spatial frequency. We also inactivated the ipsilateral visual cortex and show that one quarter of the suppression at high spatial frequencies arises from corticothalamic feedback. We show that this suppression at high spatial frequencies is colocalized with the classical surround, is not dependent on the relative orientation of the center and surround stimuli, and that the cortical component of this suppression is divisive. We propose that the role of this suppression at high spatial frequencies is to restrict the response to large stimuli composed of high spatial frequencies.
Authors:
M J Nolt; R D Kumbhani; L A Palmer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-06-27
Journal Detail:
Title:  Journal of neurophysiology     Volume:  98     ISSN:  0022-3077     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-11     Completed Date:  2008-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1167-80     Citation Subset:  IM    
Affiliation:
University of Pennsylvania School of Medicine, Department of Neuroscience, 421 Curie Blvd., 1127 BRB II/III, Philadelphia, PA 19104, USA. nolt@mail.med.upenn.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cats
Cerebral Cortex / physiology
Electroencephalography
Geniculate Bodies / physiology*
Kinetics
Membrane Potentials / physiology
Reaction Time
Retina / physiology
Space Perception / physiology
Stereotaxic Techniques
Visual Perception / physiology*
Grant Support
ID/Acronym/Agency:
R01-EY-016430/EY/NEI NIH HHS; T32-EY-007035/EY/NEI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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