Document Detail


Suppression of arousal by progesterone in fetal sheep.
MedLine Citation:
PMID:  9733059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The high rate of progesterone synthesis by the placenta in late gestation exposes the ovine fetus to high concentrations of progesterone and its metabolites that may affect activity of the fetal brain. The aim of this study was to determine the effect of inhibiting maternal progesterone synthesis on sleep-wake activity in fetal sheep. Fetal and maternal vascular catheters, a fetal tracheal catheter, and electrodes for recording fetal electrocortical (ECoG), electro-ocular (EOG) and nuchal muscle electromyographic (EMG) activity were implanted. At 128-131 days gestation, progesterone production was inhibited by an injection of trilostane (50 mg), a 3beta-hydroxysteroid dehydrogenase inhibitor. Vehicle solution or progesterone (3 mg h(-1)) was then infused into the ewe between 6 and 12 h after the trilostane treatment. Maternal progesterone concentrations were significantly reduced from 1-24 h after trilostane treatment (P < 0.05) when followed by vehicle infusion. Fetal breathing movements (FBM), EOG, nuchal muscle EMG, and behavioural arousal increased 12 h after trilostane treatment (P < 0.05). In contrast, there was no change in fetal arousal, EOG, EMG or FBM activities when progesterone was infused after the trilostane treatment. These findings show that progesterone can influence fetal behaviour, and indicates that normal progesterone production tonically suppresses arousal, or wakefulness in the fetus.
Authors:
K J Crossley; M B Nicol; J J Hirst; D W Walker; G D Thorburn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproduction, fertility, and development     Volume:  9     ISSN:  1031-3613     ISO Abbreviation:  Reprod. Fertil. Dev.     Publication Date:  1997  
Date Detail:
Created Date:  1998-12-09     Completed Date:  1998-12-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8907465     Medline TA:  Reprod Fertil Dev     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  767-73     Citation Subset:  IM    
Affiliation:
Department of Physiology, Monash University, Clayton, Vic, Australia.
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MeSH Terms
Descriptor/Qualifier:
3-Hydroxysteroid Dehydrogenases / antagonists & inhibitors
Animals
Arousal / drug effects,  physiology*
Brain / drug effects,  embryology*
Dihydrotestosterone / analogs & derivatives,  pharmacology
Electromyography
Enzyme Inhibitors / pharmacology
Female
Maternal-Fetal Exchange
Pregnancy
Progesterone / blood,  physiology*
Sheep
Sleep / drug effects,  physiology*
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 13647-35-3/trilostane; 521-18-6/Dihydrotestosterone; 57-83-0/Progesterone; EC 1.1.-/3-Hydroxysteroid Dehydrogenases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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