Document Detail


Suppression of adrenal renin in Dahl salt-sensitive rats.
MedLine Citation:
PMID:  3539795     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We previously showed that adrenal renin is highest in the rat zona glomerulosa (ZG) and that low sodium or high potassium and nephrectomy increase adrenal ZG renin and aldosterone. Dahl salt-sensitive rats (S) have been shown to have lower plasma renin activity and plasma aldosterone and higher plasma 18-hydroxy-11-deoxycorticosterone than Dahl salt-resistant rats (R). In this study we assess the possible role of adrenal ZG renin in the suppression of aldosterone in S rats. Adrenal ZG renin was significantly decreased in S as compared with R rats even at 6 weeks of age, when both S and R rats are still normotensive (S = 7.2 +/- 0.2, R = 18.0 +/- 1.6 ng angiotensin I/mg protein/hr). Adrenal ZG aldosterone was also significantly lower in S than in R rats (S = 21.1 +/- 4.3, R = 39.5 +/- 3.6 ng/mg protein). Furthermore, the rise in adrenal ZG renin and aldosterone after nephrectomy in S rats was significantly less than that in R rats. To determine if the suppressed adrenal ZG renin of S rats is due to volume expansion, we studied the effect of a sodium-deficient diet on adrenal ZG renin in S and R rats. After 2 weeks of a sodium-deficient diet S rats had significantly lower basal adrenal ZG renin than did R rats (S = 7.6 +/- 0.4, R = 21.7 +/- 1.9 ng angiotensin I/mg protein/hr) and a marked blunting of the adrenal ZG renin response to nephrectomy (S = 13.6 +/- 1.1, DR = 167 +/- 16.1 ng angiotensin I/mg protein/hr).(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
K Baba; P J Mulrow; R Franco-Saenz; J P Rapp
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  8     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-01-29     Completed Date:  1987-01-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1149-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
18-Hydroxydesoxycorticosterone / metabolism
Adrenal Cortex / enzymology*
Aldosterone / metabolism*
Animals
Diet, Sodium-Restricted
Female
Hypertension / etiology
Rats
Rats, Inbred Strains
Renin / metabolism*
Sodium Chloride / administration & dosage,  pharmacology*
Chemical
Reg. No./Substance:
0/18-Hydroxydesoxycorticosterone; 52-39-1/Aldosterone; 7647-14-5/Sodium Chloride; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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