Document Detail

Suppression of UVA-mediated release of labile iron by epicatechin--a link to lysosomal protection.
MedLine Citation:
PMID:  17015166     Owner:  NLM     Status:  MEDLINE    
UVA (320-380 nm) radiation generates an oxidative stress in cells and leads to an immediate release of potentially damaging labile iron pools in human skin cells. Treatment of cultured skin fibroblasts for several hours with physiologically relevant concentrations of either epicatechin (EC), a flavonoid plant constituent present in foods, or methylated epicatechin (3'-O-methyl epicatechin, MeOEC), its major human metabolite, prevents this iron release. The similarity of the effectiveness of EC and MeOEC argues against chelation as the mechanism of iron removal. Evidence based on measurements of lysosomal integrity strongly supports the hypothesis that the catechins protect against lysosomal destruction by UVA. Such damage would normally lead to protease release, which has been previously shown to cause ferritin degradation and release of labile iron.
Sharmila Basu-Modak; Dalia Ali; Matt Gordon; Tobias Polte; Anthie Yiakouvaki; Charareh Pourzand; Catherine Rice-Evans; Rex M Tyrrell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-06-17
Journal Detail:
Title:  Free radical biology & medicine     Volume:  41     ISSN:  0891-5849     ISO Abbreviation:  Free Radic. Biol. Med.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-03     Completed Date:  2006-11-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709159     Medline TA:  Free Radic Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1197-204     Citation Subset:  IM    
Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK.
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MeSH Terms
Catechin / pharmacology*
Cell Line
Collagenases / antagonists & inhibitors,  genetics
Fibroblasts / drug effects,  metabolism,  radiation effects
Gene Expression / drug effects
Iron / metabolism*
Iron Chelating Agents / metabolism
Lysosomes / drug effects*,  metabolism*,  radiation effects
Oxidative Stress / radiation effects
Ultraviolet Rays
Reg. No./Substance:
0/Iron Chelating Agents; 154-23-4/Catechin; 7439-89-6/Iron; EC 3.4.24.-/Collagenases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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