Document Detail

Suppression of trophoblast uterine spiral artery remodeling by estrogen during baboon pregnancy: impact on uterine and fetal blood flow dynamics.
MedLine Citation:
PMID:  22427518     Owner:  NLM     Status:  MEDLINE    
The present study was conducted to determine the impact of suppressing trophoblast remodeling of the uterine spiral arteries by prematurely elevating estrogen levels in the first trimester of baboon pregnancy on uterine and umbilical blood flow dynamics. Uteroplacental blood flow was assessed by Doppler ultrasonography after acute administration of saline (basal state) and serotonin on days 60, 100, and 160 of gestation (term: 184 days) to baboons in which uterine spiral artery remodeling had been suppressed by the administration of estradiol on days 25-59 of gestation. Maternal blood pressure in the basal state was increased (P < 0.01), and uterine artery diastolic notching and the umbilical artery pulsatility index and systolic-to-diastolic ratio, reflecting downstream flow impedance, were increased (P < 0.01) after serotonin administration on day 160, but not earlier, in baboons treated with estradiol in early gestation. These changes in uteroplacental flow dynamics in serotonin-infused, estradiol-treated animals were accompanied by a decrease (P < 0.05) in uterine and umbilical artery volume flow and fetal bradycardia. The results of this study show that suppression of uterine artery remodeling by advancing the rise in estrogen from the second trimester to the first trimester disrupted uteroplacental blood flow dynamics and fetal homeostasis after vasochallenge late in primate pregnancy.
Graham W Aberdeen; Thomas W Bonagura; Chris R Harman; Gerald J Pepe; Eugene D Albrecht
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-03-16
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  302     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-16     Completed Date:  2012-07-26     Revised Date:  2014-10-17    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H1936-44     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects,  physiology
Estradiol / blood
Estrogens / pharmacology*
Fetus / blood supply*
Heart Rate / drug effects,  physiology
Homeostasis / drug effects,  physiology
Models, Animal
Papio / physiology*
Pregnancy, Animal / physiology*
Regional Blood Flow / drug effects*,  physiology
Serotonin / pharmacology
Serotonin Receptor Agonists / pharmacology
Trophoblasts / drug effects*,  physiology
Umbilical Arteries / physiology*
Uterine Artery / drug effects*,  physiology
Grant Support
Reg. No./Substance:
0/Estrogens; 0/Serotonin Receptor Agonists; 333DO1RDJY/Serotonin; 4TI98Z838E/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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