Document Detail

Suppression of TNF-stimulated proliferation of diploid fibroblasts and TNF-induced cytotoxicity against transformed fibroblasts by TGF-beta.
MedLine Citation:
PMID:  2912446     Owner:  NLM     Status:  MEDLINE    
Human transforming growth factor-beta (TGF-beta) dose-dependently inhibited proliferation of WI-38 cells, normal human diploid fibroblasts, stimulated by tumor necrosis factor (TNF). Inhibition occurred at 1 ng/ml concentration of TGF-beta. Also, TGF-beta dose-dependently suppressed cytotoxicity of TNF against L-929 cells, murine transformed fibroblasts. The concentration of TNF required for 50% cytolysis of L-929 cells was changed from 30 ng/ml to 350 ng/ml by 10 ng/ml TGF-beta. This suppression was abolished when L-929 cells were treated with actinomycin D or cycloheximide, suggesting that TGF-beta might inhibit the action of TNF via de novo protein synthesis. This response was not due to down regulation of TNF receptors nor to alteration of the affinity of TNF for its receptor.
R Kamijo; K Takeda; M Nagumo; K Konno
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  158     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-02-17     Completed Date:  1989-02-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  155-62     Citation Subset:  IM    
1st Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan.
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MeSH Terms
Cell Division / drug effects*
Cell Line
Cell Survival / drug effects*
Fibroblasts / cytology,  drug effects
Transforming Growth Factors / pharmacology*
Tumor Necrosis Factor-alpha / antagonists & inhibitors,  pharmacology*
Reg. No./Substance:
0/Tumor Necrosis Factor-alpha; 76057-06-2/Transforming Growth Factors

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