Document Detail

Suppression of LH secretion in food-restricted lactating females: effects of ovariectomy and bromocryptine treatment.
MedLine Citation:
PMID:  7561627     Owner:  NLM     Status:  MEDLINE    
It has been shown that restricting food in lactating rats for the first 2 weeks postpartum at a level of 60% of the ad-libitum daily ration increases the length of lactational dioestrus by about 7 days but little is known about correlated changes in hormone levels. In the first experiment we report changes in LH, prolactin (PRL) and ACTH secretion in food-restricted and ad-libitum fed lactating rats at various stages of lactation. Our results demonstrate that food restriction during the first 2 weeks of lactation did not affect PRL or ACTH secretion, but decreased plasma LH levels despite comparable GnRH receptor density between food-restricted and ad-libitum fed females. In the second experiments we investigated a possible causal relationship between the increased secretion of progesterone seen in food-restricted females and the suppression of plasma LH levels, by determining the effects of bromocryptine treatment and ovariectomy on LH secretion in both ad-libitum fed and food-restricted lactating females. LH suppression in food-restricted lactating females was not affected by ovariectomy or bromocryptine treatment, although the latter treatment significantly increased GnRH receptor number. These data suggest that factors other than ovarian steroids, PRL or increased adrenocortical activity modulate LH secretion and the length of lactational dioestrus in food-restricted lactating females.
C D Walker; J B Mitchell; B C Woodside
Related Documents :
16826507 - Physiological adjustments of sand gazelles (gazella subgutturosa) to a boom-or-bust eco...
9538327 - Effect of restricted nutrition on timing of puberty in female soay sheep.
3281477 - Effect of food manipulation on the gnrh-lh-estradiol axis of young female rats.
12645857 - Food restriction and fish oil suppress atherogenic risk factors in lupus-prone (nzb x n...
12887397 - Sugar-starch combinations in food and the relationship to dental caries in low-risk ado...
19120927 - Comparison of tempo ec and tbx medium for the enumeration of escherichia coli in cheese.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  146     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-10-25     Completed Date:  1995-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  95-104     Citation Subset:  IM    
Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adrenocorticotropic Hormone / secretion
Bromocriptine / pharmacology*
Diestrus / physiology
Food Deprivation / physiology*
Lactation / physiology*
Luteinizing Hormone / secretion*
Pituitary Gland / metabolism
Progesterone / secretion
Prolactin / secretion
Rats, Wistar
Receptors, LHRH / metabolism
Reg. No./Substance:
0/Receptors, LHRH; 25614-03-3/Bromocriptine; 57-83-0/Progesterone; 9002-60-2/Adrenocorticotropic Hormone; 9002-62-4/Prolactin; 9002-67-9/Luteinizing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of hypothyroidism on the pituitary-gonadal axis in the adult female rat.
Next Document:  Retinoids: transport, metabolism, and mechanisms of action.