Document Detail

Suppression of IL-2 and IFN-gamma production in women with spontaneous preterm labor.
MedLine Citation:
PMID:  16489882     Owner:  NLM     Status:  MEDLINE    
AIMS: To determine the TH-1/TH-2 cytokine pattern in peripheral blood leukocytes (PBL) in late second- and third trimester in normal pregnancies, in comparison to patients with spontaneous preterm delivery (PTD; < 37 completed weeks' gestation). METHODS: A cross-sectional retrospective study was performed in a tertiary care obstetric unit with healthy non-pregnant women (n=7); healthy pregnant women (n=25); patients (n=25) with preterm labor (defined as uterine contractions or changes in cervical length). The phenotypic analysis of TH-1/TH-2 immune deviation was examined in PBL. RESULTS: 26% PTD (n=13) were recorded. Patients delivering at term (n=37, 74%) were characterized by an upregulation of IL-2, IFN-gamma and IL-4 production during weeks 20-25, followed by a strong suppression in cytokine production, except for TGF-beta. Towards the end of pregnancy cytokine levels returned to normal as observed in non-pregnant women. In contrast, PTD showed an inverse pattern for IL-2 and IFN-gamma with marked suppression in IL-2 and IFN-gamma production between weeks 20-25, followed by a strong stimulation of these cytokines. No differences were observed in IL-4 and TGF-beta production. CONCLUSION: An inverse pattern in IL-2 and IFN-gamma production in PBLs between weeks 20-30 is seen in PTD as compared to patients delivering at term.
Cathrin Wilke; Harald Renz; Ismail Tekesin; Lars Hellmeyer; Udo Herz; Stephan Schmidt
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  34     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  2006  
Date Detail:
Created Date:  2006-02-21     Completed Date:  2007-01-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  20-7     Citation Subset:  IM    
Department of Clinical Chemistry and Molecular Diagnostics, Central Laboratory, University Hospital Giessen and Marburg, Baldingerstrasse, 35033 Marburg, Germany.
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MeSH Terms
Cross-Sectional Studies
Interferon-gamma / biosynthesis,  immunology*
Interleukin-2 / biosynthesis,  immunology*
Interleukin-4 / biosynthesis,  immunology
Obstetric Labor, Premature / immunology*,  metabolism
Pregnancy Trimester, Third
Premature Birth
Regression Analysis
Retrospective Studies
Th1 Cells / immunology*,  metabolism
Th2 Cells / immunology*,  metabolism
Transforming Growth Factor beta / biosynthesis,  immunology
Reg. No./Substance:
0/Interleukin-2; 0/Transforming Growth Factor beta; 207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma
Erratum In:
J Perinat Med. 2006;34(34):350.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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