| Supporting sensory transduction: cochlear fluid homeostasis and the endocochlear potential. | |
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MedLine Citation:
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PMID: 16857713 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The exquisite sensitivity of the cochlea, which mediates the transduction of sound waves into nerve impulses, depends on the endocochlear potential and requires a highly specialized environment that enables and sustains sensory function. Disturbance of cochlear homeostasis is the cause of many forms of hearing loss including the most frequently occurring syndromic and non-syndromic forms of hereditary hearing loss, Pendred syndrome and Cx26-related deafness. The occurrence of these and other monogenetic disorders illustrates that cochlear fluid homeostasis and the generation of the endocochlear potential are poorly secured by functional redundancy. This review summarizes the most prominent aspects of cochlear fluid homeostasis. It covers cochlear fluid composition, the generation of the endocochlear potential, K(+) secretion and cycling and its regulation, the role of gap junctions, mechanisms of acid-base homeostasis, and Ca(2+) transport. |
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Authors:
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Philine Wangemann |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2006-07-20 |
Journal Detail:
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Title: The Journal of physiology Volume: 576 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-10-03 Completed Date: 2006-11-30 Revised Date: 2010-09-15 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: England |
Other Details:
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Languages: eng Pagination: 11-21 Citation Subset: IM |
Affiliation:
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Anatomy & Physiology Department, 205 Coles Hall, Kansas State University, Manhattan, 66506, USA. wange@vet.k-state.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium
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physiology Animals Cochlea / cytology, innervation, physiology* Evoked Potentials, Auditory / physiology* Extracellular Fluid / physiology* Gap Junctions / physiology Hearing Loss / physiopathology Homeostasis / physiology* Humans Neurons, Afferent / physiology Potassium / metabolism Potassium Channels / physiology Signal Transduction / physiology Sodium-Potassium-Exchanging ATPase / physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01-DC01098/DC/NIDCD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Potassium Channels; 7440-09-7/Potassium; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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