Document Detail

Supporting, microporous, elastomeric, degradable prostheses to improve the arterialization of autologous vein grafts.
MedLine Citation:
PMID:  8011864     Owner:  NLM     Status:  MEDLINE    
Arterial reconstructions with vein grafts fail more frequently than with arterial grafts. One of the causes of graft failure is damage due to overstretching of the graft wall. Overstretching is caused because the vein graft, which has a poorly developed medium, cannot withstand the arterial blood pressures. The aim of this study is to evaluate whether damage due to overstretching can be prevented and a gradual adaptation of the vein graft to the arterial blood pressures can be induced by applying a microporous, elastomeric, degradable prosthesis around the vein graft. Therefore, autologous vein grafts (length 1.0 cm) with and without supporting prostheses (composite vein grafts and control vein grafts, respectively) were interposed into both carotid arteries of rabbits. Microporous, elastomeric, biofragmentable polyurethane-based prostheses and microporous, elastomeric, biodegradable prostheses made of poly-epsilon-caprolactone or a copolymer of epsilon-caprolactone and 3.6-dimethyl-1,4-morpholine-2,5-dione with a monomer ratio of 95.5:4.5 were prepared. The grafts were evaluated up to 6 wk after implantation. The control vein grafts showed severe destructive changes such as de-endothelialization, disruption of the media with oedema, degradation of the elastic laminae and infiltration of polymorphonuclear leucocytes into the vein graft wall, leading eventually to a fibrotic wall. In contrast, the composite vein grafts showed a preservation of the smooth muscle cell layers and the elastic laminae with only few polymorphonuclear leucocytes infiltrated into the vein graft wall.(ABSTRACT TRUNCATED AT 250 WORDS)
W L Hinrichs; H P Zweep; S Satoh; J Feijen; C R Wildevuur
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biomaterials     Volume:  15     ISSN:  0142-9612     ISO Abbreviation:  Biomaterials     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-07-25     Completed Date:  1994-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  83-91     Citation Subset:  IM    
Department of Chemical Technology, University of Twente, Enschede, The Netherlands.
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MeSH Terms
Biocompatible Materials
Biodegradation, Environmental
Blood Vessel Prosthesis / adverse effects,  standards*
Carotid Arteries / surgery
Microscopy, Electron, Scanning
Reg. No./Substance:
0/Biocompatible Materials

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