| Support of the preterm circulation: keynote address to the Fifth Evidence vs Experience Conference, Chicago, June 2008. | |
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MedLine Citation:
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PMID: 19399010 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hemodynamics is an area of neonatology that is marked more by what we do not know than what we do. What is clear is that it is much more complex than just measuring blood pressure (BP). Early postnatal preterm hemodynamic pathophysiology is characterized by low systemic blood flow (SBF), possibly relating to a mix of afterload compromise, left-to-right shunting through the unconstricted ductus and to the circulatory effects of ventilation. After approximately 24 h of age, vasodilatation seems to be the dominant pathology. In the face of this complexity, a one-size-fits-all approach to treatment that will be applicable in a large clinical trial may prove elusive. The possibility of using a measure of both BP and SBF to target an appropriate treatment needs to be explored. |
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Authors:
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N Evans |
Publication Detail:
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Type: Addresses; Case Reports |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 29 Suppl 2 ISSN: 1476-5543 ISO Abbreviation: J Perinatol Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-28 Completed Date: 2009-08-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: S50-7 Citation Subset: IM |
Affiliation:
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Department of Newborn Care, Royal Prince Alfred Hospital and University of Sydney, Sydney, NSW, Australia. nevans@med.usyd.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity
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drug effects,
physiology Blood Pressure / drug effects, physiology Brain Ischemia / physiopathology, therapy Cardiac Output, Low / physiopathology, therapy Cardiotonic Agents / therapeutic use Combined Modality Therapy Dobutamine / therapeutic use Dopamine / therapeutic use Ductus Arteriosus, Patent / physiopathology, therapy Evidence-Based Medicine* Hemodynamics / drug effects, physiology* Homeostasis / drug effects, physiology Humans Infant, Newborn Infant, Premature, Diseases / physiopathology*, therapy* Intensive Care, Neonatal Male Positive-Pressure Respiration / methods Randomized Controlled Trials as Topic Regional Blood Flow / drug effects, physiology Ultrasonography, Doppler Ultrasonography, Doppler, Transcranial |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 34368-04-2/Dobutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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