Document Detail


Support for the involvement of the ERBB4 gene in schizophrenia: a genetic association analysis.
MedLine Citation:
PMID:  20600594     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cellular, animal and human studies support the involvement of aberrant NRG-ErbB signaling in the pathogenesis of schizophrenia. The aim of the present study was to examine whether genetic variation in the human ERBB4 gene is associated with susceptibility to schizophrenia. Two hundred and twenty-seven unrelated chronic inpatients with schizophrenia were enrolled in the study, and the genetic variation in the polymorphisms of the ERBB4 gene in the patients was compared with that of the control group, which consisted of 223 subjects free of psychiatric illness. The results showed that one coding-synonymous polymorphism (rs3748962, Val1065Val) was in genotypic (p=0.0027) and allelic (p=0.0007) association with schizophrenia. In comparison with subjects of the rs3748962-TT type, those of the rs3748962-CT and rs3748962-CC types were at 1.74- and 2.64-fold greater risk of schizophrenia (CT vs. TT: OR=1.71 (95% CI=1.15-2.53), p=0.0014; CC vs. TT: OR=2.64 (95% CI=1.37-5.23), p=0.0047), which supports the hypothesis of an additive model of transmission (p=0.0006). Furthermore, the frequency of haplotype ATC of rs3791709-rs2289086-rs3748962 was found to be significantly higher in the patients with schizophrenia than in the controls (case vs. control=36.0% vs. 24.4%, permutation p-value=0.0002). The findings support the involvement of the ERBB4 gene in schizophrenia in Han Chinese.
Authors:
Chao-Lin Lu; Ying-Chieh Wang; Jen-Yeu Chen; I-Ching Lai; Ying-Jay Liou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-26
Journal Detail:
Title:  Neuroscience letters     Volume:  481     ISSN:  1872-7972     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-03     Completed Date:  2010-11-22     Revised Date:  2011-11-02    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  120-5     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Psychiatric Division, Hualien Armed Forces General Hospital, Hualien, Taiwan, ROC.
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MeSH Terms
Descriptor/Qualifier:
Adult
Asian Continental Ancestry Group / ethnology,  genetics
Female
Gene Frequency
Genetic Predisposition to Disease*
Genome-Wide Association Study
Genotype
Humans
Linkage Disequilibrium
Male
Middle Aged
Polymorphism, Single Nucleotide / genetics*
Receptor, Epidermal Growth Factor / genetics*
Schizophrenia / genetics*
Taiwan
Chemical
Reg. No./Substance:
EC 2.7.10.1/Receptor, Epidermal Growth Factor; EC 2.7.10.1/receptor tyrosine-protein kinase erbB-4

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