| Supplementing vitamin B6 to a low vitamin B6 diet exaggerates UVB-induced skin tumorigenesis in DMBA-treated hairless mice. | |
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MedLine Citation:
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PMID: 18635915 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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7,12-Dimethylbenz[a]anthracene (DMBA)-treated hairless mice exposed to UVB radiation were used to examine the effect of graded levels of vitamin B(6) [1, 7 or 35 mg pyridoxine (PN) HCl/kg] on skin tumorigenesis for 18 wk. Compared to the 1 mg PN HCl/kg diet, the 35 mg PN HCl/kg diet significantly elevated the incidence and multiplicity of skin tumors, while there was no difference in skin tumorigenesis between the 7 and 35 mg PN HCl/kg diets. Skin levels of oxidative stress markers (lipid peroxides and protein carbonyls) were unaffected by dietary treatment. Compared to the 1 mg PN HCl/kg diet, the 7 and 35 mg PN HCl/kg diets significantly elevated serum pyridoxal 5'-phosphate (PLP) without affecting the skin level of PLP. The results suggest that dietary supplemental vitamin B(6) exaggerates UVB-induced skin tumorigenesis in hairless mice without affecting oxidative stress in the skin. |
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Authors:
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Tao Lu; Yonghui Xu; Elise Saiz Monttinen; Norihisa Kato |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of nutritional science and vitaminology Volume: 54 ISSN: 0301-4800 ISO Abbreviation: J. Nutr. Sci. Vitaminol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-07-18 Completed Date: 2008-12-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0402640 Medline TA: J Nutr Sci Vitaminol (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 262-5 Citation Subset: IM |
Affiliation:
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Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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9,10-Dimethyl-1,2-benzanthracene
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administration & dosage* Animals Biological Markers / blood, metabolism Carcinogens / administration & dosage Diet / adverse effects, methods Dietary Supplements / adverse effects* Dose-Response Relationship, Drug Female Mice Mice, Hairless Oxidative Stress / drug effects, radiation effects Pyridoxal Phosphate / blood Pyridoxine / metabolism, pharmacology Skin / drug effects, metabolism, radiation effects Skin Neoplasms / blood, metabolism* Thiobarbituric Acid Reactive Substances / metabolism Ultraviolet Rays / adverse effects* Vitamin B 6 / adverse effects, metabolism, pharmacology* Vitamin B 6 Deficiency / drug therapy, metabolism* Vitamin B Complex / adverse effects, metabolism, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Carcinogens; 0/Thiobarbituric Acid Reactive Substances; 12001-76-2/Vitamin B Complex; 54-47-7/Pyridoxal Phosphate; 57-97-6/9,10-Dimethyl-1,2-benzanthracene; 65-23-6/Pyridoxine; 8059-24-3/Vitamin B 6 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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