Document Detail

Supplementing vitamin B6 to a low vitamin B6 diet exaggerates UVB-induced skin tumorigenesis in DMBA-treated hairless mice.
MedLine Citation:
PMID:  18635915     Owner:  NLM     Status:  MEDLINE    
7,12-Dimethylbenz[a]anthracene (DMBA)-treated hairless mice exposed to UVB radiation were used to examine the effect of graded levels of vitamin B(6) [1, 7 or 35 mg pyridoxine (PN) HCl/kg] on skin tumorigenesis for 18 wk. Compared to the 1 mg PN HCl/kg diet, the 35 mg PN HCl/kg diet significantly elevated the incidence and multiplicity of skin tumors, while there was no difference in skin tumorigenesis between the 7 and 35 mg PN HCl/kg diets. Skin levels of oxidative stress markers (lipid peroxides and protein carbonyls) were unaffected by dietary treatment. Compared to the 1 mg PN HCl/kg diet, the 7 and 35 mg PN HCl/kg diets significantly elevated serum pyridoxal 5'-phosphate (PLP) without affecting the skin level of PLP. The results suggest that dietary supplemental vitamin B(6) exaggerates UVB-induced skin tumorigenesis in hairless mice without affecting oxidative stress in the skin.
Tao Lu; Yonghui Xu; Elise Saiz Monttinen; Norihisa Kato
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nutritional science and vitaminology     Volume:  54     ISSN:  0301-4800     ISO Abbreviation:  J. Nutr. Sci. Vitaminol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-07-18     Completed Date:  2008-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0402640     Medline TA:  J Nutr Sci Vitaminol (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  262-5     Citation Subset:  IM    
Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, Japan.
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MeSH Terms
9,10-Dimethyl-1,2-benzanthracene / administration & dosage*
Biological Markers / blood,  metabolism
Carcinogens / administration & dosage
Diet / adverse effects,  methods
Dietary Supplements / adverse effects*
Dose-Response Relationship, Drug
Mice, Hairless
Oxidative Stress / drug effects,  radiation effects
Pyridoxal Phosphate / blood
Pyridoxine / metabolism,  pharmacology
Skin / drug effects,  metabolism,  radiation effects
Skin Neoplasms / blood,  metabolism*
Thiobarbituric Acid Reactive Substances / metabolism
Ultraviolet Rays / adverse effects*
Vitamin B 6 / adverse effects,  metabolism,  pharmacology*
Vitamin B 6 Deficiency / drug therapy,  metabolism*
Vitamin B Complex / adverse effects,  metabolism,  pharmacology
Reg. No./Substance:
0/Biological Markers; 0/Carcinogens; 0/Thiobarbituric Acid Reactive Substances; 12001-76-2/Vitamin B Complex; 54-47-7/Pyridoxal Phosphate; 57-97-6/9,10-Dimethyl-1,2-benzanthracene; 65-23-6/Pyridoxine; 8059-24-3/Vitamin B 6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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