Document Detail

Supplementing transglucosidase with a high-fiber diet for prevention of postprandial hyperglycemia in streptozotocin-induced diabetic dogs.
MedLine Citation:
PMID:  20165914     Owner:  NLM     Status:  MEDLINE    
Indigestible oligosaccharides have been shown to normalize blood glucose and insulin concentration thereby promoting good health and preventing diseases, such as diabetes. Transglucosidase (TG, alpha-glucosidase, enzyme code (EC) is an enzyme capable of converting starch to oligosaccharides, such as iso-malto-oligosaccharides from maltose, via the action of amylase. The aim of this study was to evaluate whether oral administration of TG with maltose or dextrin is capable of reducing post-prandial serum glucose concentration in experimentally streptozotocin (STZ)-induced diabetic dogs fed on a high-fiber diet. Five healthy and five STZ-induced diabetic dogs were employed in this study. TG supplementation with dextrin or maltose had no detrimental effect in healthy dogs. In fact, TG and dextrin exhibited a flatlined serum glucose pattern, while reducing mean post-prandial serum insulin and glucose concentration as compared to control diet alone. When TG supplementation was tested in STZ-induced diabetic dogs under the context of a high fiber diet, a 13.8% and 23.9% reduction in mean glucose concentration for TG with maltose and dextrin, respectively was observed. Moreover, TG with dextrin resulted in a 13% lower mean post-prandial glucose concentration than TG with maltose, suggesting that dextrin may be a more efficient substrate than maltose when used at the same concentration (1 g/kg). Our results indicate that TG supplementation with diet can lead to lower postprandial glucose levels versus diet alone. However, the efficacy of TG supplementation may depend on the type of diet it is supplemented with. As such, TG administration may be useful for preventing the progression of diabetes mellitus and in its management in dogs.
Toshinori Sako; Akihiro Mori; Peter Lee; Hiroshi Goto; Hiroko Fukuta; Hitomi Oda; Kaori Saeki; Yohei Miki; Yuki Makino; Katsumi Ishioka; Hisashi Mizutani; Yuzo Kojima; Satoshi Koikeda; Toshiro Arai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-18
Journal Detail:
Title:  Veterinary research communications     Volume:  34     ISSN:  1573-7446     ISO Abbreviation:  Vet. Res. Commun.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-03     Completed Date:  2010-05-28     Revised Date:  2011-03-25    
Medline Journal Info:
Nlm Unique ID:  8100520     Medline TA:  Vet Res Commun     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  161-72     Citation Subset:  IM    
School of Veterinary Nursing & Technology, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo, 180-8602, Japan.
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MeSH Terms
Area Under Curve
Blood Glucose / metabolism
Dextrins / administration & dosage,  metabolism
Diabetes Mellitus, Experimental / diet therapy,  metabolism,  prevention & control*
Diabetes Mellitus, Type 1 / diet therapy,  metabolism,  prevention & control,  veterinary*
Dietary Fiber / administration & dosage*,  metabolism
Dietary Supplements
Dog Diseases / diet therapy*,  metabolism,  prevention & control
Glucosidases / administration & dosage*,  metabolism
Hyperglycemia / metabolism,  prevention & control,  veterinary*
Insulin / blood
Maltose / administration & dosage,  metabolism
Reg. No./Substance:
0/Blood Glucose; 0/Dextrins; 11061-68-0/Insulin; 69-79-4/Maltose; EC 3.2.1.-/Glucosidases
Comment In:
Vet Res Commun. 2011 Mar;35(3):131-2   [PMID:  21271288 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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