| Supplementing iron and zinc: double blind, randomized evaluation of separate or combined delivery. | |
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MedLine Citation:
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PMID: 19904293 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/OBJECTIVES: Many children have diets deficient in both iron and zinc, but there has been some evidence of negative interactions when they are supplemented together. The optimal delivery approach would maximize clinical benefits of both nutrients. We studied the effectiveness of different iron and zinc supplement delivery approaches to improve diarrhea and anemia in a rural Bangladesh population. STUDY DESIGN: Randomized, double blind, placebo-controlled factorial community trial. RESULTS: Iron supplementation alone increased diarrhea, but adding zinc, separately or together, attenuated these harmful effects. Combined zinc and iron was as effective as iron alone for iron outcomes. All supplements were vomited <1% of the time, but combined iron and zinc were vomited significantly more than any of the other supplements. Children receiving zinc and iron (together or separately) had fewer hospitalizations. Separating delivery of iron and zinc may have some additional benefit in stunted children. CONCLUSIONS: Separate and combined administration of iron and zinc are equally effective for reducing diarrhea, hospitalizations and improving iron outcomes. There may be some benefit in separate administration in stunted children. |
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Authors:
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S Chang; S El Arifeen; S Bari; M A Wahed; K M Rahman; M T Rahman; A B A Mahmud; N Begum; K Zaman; A H Baqui; R E Black |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-11-11 |
Journal Detail:
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Title: European journal of clinical nutrition Volume: 64 ISSN: 1476-5640 ISO Abbreviation: Eur J Clin Nutr Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-04-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 153-60 Citation Subset: IM |
Affiliation:
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Johns Hopkins Medical Institutions, Agency for Healthcare Research and Quality, Rockville, MD, USA. Stephanie.chang@ahrq.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Iron-Deficiency
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complications,
drug therapy* Deficiency Diseases / drug therapy* Diarrhea / epidemiology, etiology, prevention & control Dietary Supplements* Double-Blind Method Drug Therapy, Combination Female Growth Disorders / drug therapy* Hospitalization Humans Incidence Infant Iron / adverse effects, deficiency, therapeutic use* Male Vomiting Zinc / deficiency, pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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7439-89-6/Iron; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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