Document Detail

Supplementation with a whey protein hydrolysate enhances recovery of muscle force-generating capacity following eccentric exercise.
MedLine Citation:
PMID:  18768358     Owner:  NLM     Status:  MEDLINE    
There is evidence that protein hydrolysates can speed tissue repair following damage and may therefore be useful for accelerating recovery from exercise induced muscle damage. The potential for a hydrolysate (WPI(HD)) of whey protein isolate (WPI) to speed recovery following eccentric exercise was evaluated by assessing effects on recovery of peak isometric torque (PIT). In a double-blind randomised parallel trial, 28 sedentary males had muscle soreness (MS), serum creatine kinase (CK) activity, plasma TNFalpha, and PIT assessed at baseline and after 100 maximal eccentric contractions (ECC) of their knee extensors. Participants then consumed 250 ml of flavoured water (FW; n=11), or FW containing 25 g WPI (n=11) or 25 g WPI(HD) (n=6) and the assessments were repeated 1, 2, 6 and 24h later. PIT decreased approximately 23% following ECC, remained suppressed in FW and WPI, but recovered fully in WPI(HD) by 6h (P=0.006, treatment x time interaction). MS increased following ECC (P<0.001 for time), and remained elevated with no difference between groups (P=0.61). TNFalpha and CK did not change (P>0.45). WPI(HD) may be a useful supplement for assisting athletes to recover from fatiguing eccentric exercise.
Jonathan D Buckley; Rebecca L Thomson; Alison M Coates; Peter R C Howe; Mark O DeNichilo; Michelle K Rowney
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-09-02
Journal Detail:
Title:  Journal of science and medicine in sport / Sports Medicine Australia     Volume:  13     ISSN:  1878-1861     ISO Abbreviation:  J Sci Med Sport     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-04     Completed Date:  2010-05-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812598     Medline TA:  J Sci Med Sport     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  178-81     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2008 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.
Australian Technology Network Centre for Metabolic Fitness and Nutritional Physiology Research Centre, University of South Australia, Adelaide, South Australia, Australia.
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MeSH Terms
Analysis of Variance
Creatine Kinase / blood
Double-Blind Method
Exercise / physiology*
Exercise Test
Isometric Contraction / drug effects,  physiology
Knee Joint / drug effects,  physiology
Milk Proteins / administration & dosage*
Muscle Fatigue / drug effects*,  physiology*
Muscle Strength Dynamometer
Muscle, Skeletal / drug effects*,  physiopathology*
Pain Measurement
Physical Exertion / physiology
Young Adult
Reg. No./Substance:
0/Milk Proteins; 0/whey protein; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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