Document Detail


Supplementation with alpha-linolenic acid-rich diacylglycerol suppresses fatty liver formation accompanied by an up-regulation of beta-oxidation in Zucker fatty rats.
MedLine Citation:
PMID:  15863369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Insulin resistance-related obesity and diabetes mellitus are the predominant causes of fatty liver disease. Here we examine the effects of dietary diacylglycerol (DG), which is a minor component of plant oils, on lipid accumulation and the expression of genes involved in lipid metabolism in the liver. The animals were fed diets containing either 10% triacylglycerol (TG), 10% TG + 4% alpha-linolenic acid-rich TG (ALATG) or 10% TG + 4% alpha-linolenic acid-rich diacylglycerol (ALADG) for a period of 1 month. Supplementation with ALADG significantly inhibited hepatic triglyceride accumulation; this was accompanied by the up-regulation of beta-oxidation activity, and acyl-CoA oxidase (ACO) and medium-chain acyl-CoA dehydrogenase (MCAD) mRNA levels. By contrast, no significant changes were observed in the levels of peroxisome proliferator-activated receptor-alpha (PPARalpha) and sterol regulatory element-binding protein-1 (SREBP-1) mRNAs. These results indicate that ALADG might be useful in the prevention of fatty liver formation; this effect could be closely related to the stimulation of lipid catabolism in the liver. In addition, our findings suggest that both acylglycerol structure (that is, the structural difference between TG and DG) and fatty-acid species affect the nutritional behaviour of dietary lipids.
Authors:
Takatoshi Murase; Masafumi Aoki; Ichiro Tokimitsu
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Publication Detail:
Type:  Journal Article     Date:  2005-01-13
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1733     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-05-02     Completed Date:  2005-06-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  224-31     Citation Subset:  IM    
Affiliation:
Biological Science Laboratories, Kao Corporation, Ichikai-machi, Haga-gun, Tochigi, Japan. murase.takatoshi@kao.co.jp
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MeSH Terms
Descriptor/Qualifier:
3-Hydroxyacyl CoA Dehydrogenases / antagonists & inhibitors
Acetyl-CoA C-Acyltransferase / antagonists & inhibitors
Animals
Body Weight / drug effects
Carbon-Carbon Double Bond Isomerases / antagonists & inhibitors
Cholesterol / blood,  metabolism
Diabetes Mellitus, Type 2 / blood,  drug therapy*,  metabolism
Diet
Diglycerides / administration & dosage,  chemistry,  pharmacology*
Enoyl-CoA Hydratase / antagonists & inhibitors
Fatty Liver / blood,  metabolism,  prevention & control*
Liver / drug effects,  metabolism
Male
Organ Size / drug effects
Racemases and Epimerases / antagonists & inhibitors
Rats
Rats, Zucker
Triglycerides / blood,  metabolism
alpha-Linolenic Acid / administration & dosage,  chemistry,  pharmacology*
Chemical
Reg. No./Substance:
0/Diglycerides; 0/Triglycerides; 0/fatty acid oxidation complex; 463-40-1/alpha-Linolenic Acid; 57-88-5/Cholesterol; EC 1.1.1.35/3-Hydroxyacyl CoA Dehydrogenases; EC 2.3.1.16/Acetyl-CoA C-Acyltransferase; EC 4.2.1.17/Enoyl-CoA Hydratase; EC 5.1.-/Racemases and Epimerases; EC 5.3.3.-/Carbon-Carbon Double Bond Isomerases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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