| Supplementation with EPA or fish oil for 11 months lowers circulating lipids, but does not delay the onset of diabetes in UC Davis-type 2 diabetes mellitus rats. | |
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MedLine Citation:
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PMID: 20735878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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EPA or fish oil supplementation has been suggested as treatments for the prevention of type 2 diabetes mellitus (T2DM) due to their lipid-lowering and potential insulin-sensitising effects. We investigated the effects of supplementation with EPA (1 g/kg body weight per d) or fish oil (3 g/kg body weight per d) on the age of onset of T2DM and circulating glucose, insulin, lipids, leptin and adiponectin in UC Davis (UCD)-T2DM rats. Animals were divided into three groups starting at 1 month of age: control, EPA and fish oil. All the animals were followed until diabetes onset or for up to 12 months of age. Monthly fasting blood samples were collected for the measurement of glucose, lipids, hormones and C-reactive protein (CRP). Neither EPA nor fish oil delayed the onset of T2DM or altered fasting plasma glucose, insulin, CRP, adiponectin or leptin concentrations. The groups did not differ in energy intake or body weight. Fish oil treatment lowered fasting plasma TAG concentrations by 39 (sd 7) % (P < 0.001) and EPA lowered fasting plasma NEFA concentrations by 23 (sd 5) % (P < 0.05) at 4 months of age compared with the control group. EPA and fish oil lowered fasting plasma cholesterol concentrations at 4 months of age by 19 (sd 4) and 22 (sd 4) % compared with the control group, respectively (both P < 0.01). In conclusion, EPA and fish oil supplementation lowers circulating lipid concentrations, but does not delay the onset of T2DM in UCD-T2DM rats. |
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Authors:
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Bethany P Cummings; Kimber L Stanhope; James L Graham; Steven C Griffen; Peter J Havel |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-08-24 |
Journal Detail:
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Title: The British journal of nutrition Volume: 104 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-01 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 1628-34 Citation Subset: IM |
Affiliation:
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Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age of Onset Animals Cholesterol / blood Diabetes Mellitus, Type 2 / blood*, prevention & control Dietary Fats / administration & dosage* Dietary Supplements* Eicosapentaenoic Acid / pharmacology* Fatty Acids, Nonesterified / blood Fish Oils / pharmacology* Hypolipidemic Agents / pharmacology* Lipids / blood* Male Rats Rats, Inbred Strains Triglycerides / blood |
| Grant Support | |
ID/Acronym/Agency:
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AT002599/AT/NCCAM NIH HHS; AT002993/AT/NCCAM NIH HHS; AT003645/AT/NCCAM NIH HHS; R01 HL075675/HL/NHLBI NIH HHS; R01 HL091333/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Fatty Acids, Nonesterified; 0/Fish Oils; 0/Hypolipidemic Agents; 0/Lipids; 0/Triglycerides; 1553-41-9/Eicosapentaenoic Acid; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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