| Supplementation of a maternal low-protein diet in rat pregnancy with folic acid ameliorates programming effects upon feeding behaviour in the absence of disturbances to the methionine-homocysteine cycle. | |
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MedLine Citation:
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PMID: 19941678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maternal protein restriction in rat pregnancy is associated with altered feeding behaviour in later life. When allowed to self-select their diet, rats subject to prenatal undernutrition show an increased preference for fatty foods. The main aim of the present study was to evaluate the contribution of folic acid in the maternal diet to programming of appetite, since disturbances of the folate and methionine-homocysteine cycles have been suggested to impact upon epigenetic regulation of gene expression and hence programme long-term physiology and metabolism. Pregnant rats were fed diets containing either 9 or 18 % casein by weight, with folate provided at either 1 or 5 mg/kg diet. Adult male animals exposed to low protein (LP) in fetal life exhibited increased preference for high-fat food. Providing the higher level of folate in the maternal diet prevented this effect of LP, but offspring of rats fed 18 % casein diet with additional folate behaved in a similar manner to LP-exposed animals. Among day 20 gestation fetuses, it was apparent that both protein restriction and maternal folate supplementation could have adverse effects upon placental growth. Examination of methionine-homocysteine and folate cycle intermediates, tissue glutathione concentrations and expression of mRNA for methionine synthase, DNA methyltransferase 1 and methyltetrahydrofolate reductase revealed no gross disturbances of folate and one-carbon metabolism in either maternal or fetal tissue. The present findings indicated that any role for DNA methylation in programming of physiology is not related to major perturbations of folate metabolism, and is likely to be gene-specific rather than genome-wide. |
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Authors:
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Sarah F Engeham; Andrea Haase; Simon C Langley-Evans |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-27 |
Journal Detail:
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Title: The British journal of nutrition Volume: 103 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-08 Completed Date: 2010-04-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 996-1007 Citation Subset: IM |
Affiliation:
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School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Appetite Regulation Caseins / administration & dosage DNA Methylation Diet, Protein-Restricted* Dietary Fats Dietary Supplements Enzymes / genetics, metabolism Female Folic Acid / metabolism, pharmacology* Food Preferences* Glutathione / metabolism Homocysteine / metabolism* Male Methionine / metabolism* Placenta / growth & development Pregnancy Prenatal Exposure Delayed Effects* Prenatal Nutritional Physiological Phenomena RNA, Messenger / metabolism Rats Rats, Wistar Vitamin B Complex / metabolism, pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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//Biotechnology and Biological Sciences Research Council |
| Chemical | |
Reg. No./Substance:
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0/Caseins; 0/Dietary Fats; 0/Enzymes; 0/RNA, Messenger; 12001-76-2/Vitamin B Complex; 454-28-4/Homocysteine; 59-30-3/Folic Acid; 63-68-3/Methionine; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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