| Supplementation of infant formula with the probiotic lactobacillus reuteri and zinc: impact on enteric infection and nutrition in infant rhesus monkeys. | |
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MedLine Citation:
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PMID: 12187291 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gut colonization by may have beneficial effects on infant health or capacity to resist infectious disease. Zinc supplementation has also been proposed to increase infants' resistance to disease; however, many studies have yielded conflicting results. OBJECTIVES: To study effects of probiotic supplementation of infant formula (with or without supplemental zinc) on nutritional status, gut colonization and the ability to resist gastrointestinal infection in an infant rhesus monkey model. METHODS: Infant monkeys were fed control infant formula (5 mg Zn/L), control formula with or control formula with and supplemental zinc (15 mg Zn/L) from birth to 4 months. Growth, nutritional status, mineral absorption, intestinal colonization and frequency and severity of enteropathogenic -induced gastroenteritis were monitored. RESULTS: Gastrointestinal colonization was achieved and was associated with increased ileal villous surface area and improved hematocrit, with no adverse effects on growth or nutritional indices. Fortification to 15 mg Zn/L reduced plasma copper, erythrocyte Cu/Zn-superoxide dismutase, hemoglobin, and iron absorption. Infants fed -supplemented formula had reduced diarrhea severity throughout the study period and recovered more rapidly from acute diarrhea than the other groups. CONCLUSION: -supplementation of infant formula is safe, improves iron status and decreases diarrhea severity in infant rhesus monkeys and thus may help protect formula-fed human infants from infection and nutritional deficiencies. |
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Authors:
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Shannon L Kelleher; Ivan Casas; Noris Carbajal; Bo Lönnerdal |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pediatric gastroenterology and nutrition Volume: 35 ISSN: 0277-2116 ISO Abbreviation: J. Pediatr. Gastroenterol. Nutr. Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-08-20 Completed Date: 2002-12-10 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8211545 Medline TA: J Pediatr Gastroenterol Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 162-8 Citation Subset: IM |
Affiliation:
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Department of Nutrition, University of California, Davis California 95616, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Bottle Feeding Diarrhea / prevention & control* Dietary Supplements Digestive System / microbiology*, ultrastructure Feces / microbiology Humans Infant Infant Food* Infant Nutritional Physiological Phenomena Infant, Newborn Iron / metabolism Lactobacillus / growth & development* Macaca mulatta Microscopy, Electron, Scanning Models, Animal Nutritional Status Probiotics / administration & dosage* Severity of Illness Index Zinc / administration & dosage*, metabolism |
| Chemical | |
Reg. No./Substance:
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7439-89-6/Iron; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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