| Supplementation of enteral nutrition with butyrate leads to increased portal efflux of amino acids in growing pigs with short bowel syndrome. | |
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MedLine Citation:
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PMID: 8801305 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previously, short-chain fatty acids (SCFAs) infused into the hindgut or administered intravenously have been shown to stimulate intestinal adaptation after massive small bowel resection. To study the effects of enterally supplemented n-butyrate on food digestion and absorption in growing pigs with short bowel syndrome, the authors examined the portal efflux of glucose and amino acids during a meal. In 12 growing pigs, 75% of the small intestine was resected. Five control (CONT) animals underwent transection and reanastomosis of the small bowel. A splenic vein, the aorta, the portal vein, and the stomach were catheterized. Postoperatively, seven enterectomized (ENT) pigs and the CONT pigs were fed by infusion of a liquid diet, without SCFAs, through the gastrostomy catheter. Five enterectomized animals received the same diet, supplemented with butyrate (ENTB) (0.26 g/kg body weight/d). After 3 weeks, the portal efflux of amino acids and glucose was measured after 2 hours of constant feeding. The portal efflux of glucose expressed per kilogram of body weight in the ENT group was 10% of that in the CONT group, and in the ENTB group it was 42%. No significant difference in portal glucose efflux between the ENT and the ENTB groups was found. The portal efflux of amino acids during a meal in the ENT group in relation to the CONT groups was 34%; in the ENTB group it was 63%. These data suggest that enteral supplementation with SCFAs leads to improvement of intestinal food digestion and absorption during short bowel syndrome, possibly related to improved intestinal adaptation. |
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Authors:
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C F Welters; N E Deutz; C H Dejong; P B Soeters; E Heineman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pediatric surgery Volume: 31 ISSN: 0022-3468 ISO Abbreviation: J. Pediatr. Surg. Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-10-02 Completed Date: 1996-10-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0052631 Medline TA: J Pediatr Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 526-9 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Limburg, Maastricht, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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blood* Animals Animals, Newborn Blood Glucose / metabolism Butyric Acid Butyric Acids / administration & dosage* Digestion / physiology Enteral Nutrition* Female Food, Formulated Intestinal Absorption / physiology Portal Vein Short Bowel Syndrome / physiopathology* Swine |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Blood Glucose; 0/Butyric Acids; 107-92-6/Butyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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