Document Detail


Supplementation of diets for lactating sows with zinc amino acid complex and gastric nutriment-intubation of suckling pigs with zinc methionine on mineral status, intestinal morphology and bacterial translocation in lipopolysaccharide-challenged weaned pigs.
MedLine Citation:
PMID:  19364376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sixty-four pigs from 16 sows were used to evaluate addition of zinc amino acid complex (ZnAA) to lactating sows and gastric nutriment-intubation of zinc methionine (ZnMet) to suckling pigs on mineral status, intestinal morphology and bacterial translocation after weaning. Sows were fed a barley-based diet supplying 120 ppm zinc (Zn; control) or the control diet supplemented with 240 ppm Zn from ZnAA. At birth, day-10 and day-21 (weaning) of age, pigs from each litter were nutriment-intubated with 5 ml of an electrolyte solution without or with 40 mg Zn from ZnMet. At weaning, 24 h prior to the collection of small and large intestinal lymph nodes and sections of the duodenum, jejunum and ileum, the pigs received an intramuscular injection of saline without or with 150 microg/kg body weight of Escherichia coli O26:B6 lipopolysaccharide (LPS). With the exception of a tendency (p = 0.09) for lower serum concentration of copper in pigs at weaning from ZnAA-supplemented sows, there were no differences (p > 0.1) than for pigs from control-fed sows for mineral status or intestinal morphology. Nutriment-intubation of ZnMet increased serum (p = 0.001) and liver (p = 0.003) Zn concentrations, number of goblet cells per 250 microm length of jejunal villous epithelium (p = 0.001) and tended (p = 0.06) to enhance jejunum mucosa thickness. Interactive effects (p < 0.05) for higher jejunal villi height and villi:crypt ratio and increased ileal goblet cell counts were apparent for pigs from ZnAA-supplemented sows that also received nutriment-intubation of ZnMet. Challenge with LPS increased (p = 0.05) ileal villous width. Nutriment-intubation of ZnMet decreased (p = 0.05) anaerobic bacteria colony forming unit counts in the large intestinal mesenteric lymph nodes. In conclusion, nutriment-intubation of ZnMet increased serum and liver tissue concentrations of Zn and resulted in limited improvement to intestinal morphology of weaned pigs.
Authors:
B U Metzler-Zebeli; W R Caine; M McFall; B Miller; T L Ward; R N Kirkwood; R Mosenthin
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-31
Journal Detail:
Title:  Journal of animal physiology and animal nutrition     Volume:  94     ISSN:  1439-0396     ISO Abbreviation:  J Anim Physiol Anim Nutr (Berl)     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-05-14     Completed Date:  2010-08-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101126979     Medline TA:  J Anim Physiol Anim Nutr (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  237-49     Citation Subset:  IM    
Affiliation:
Institute of Animal Nutrition, University of Hohenheim, Stuttgart, Germany.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / chemistry,  pharmacology*
Animal Feed / analysis
Animal Nutritional Physiological Phenomena
Animals
Animals, Suckling
Diet / veterinary
Dietary Supplements
Female
Intestines / anatomy & histology*,  microbiology
Lactation
Lipopolysaccharides / toxicity
Methionine / analogs & derivatives*,  chemistry,  pharmacology
Minerals / metabolism*
Nutritional Status
Organometallic Compounds / chemistry,  pharmacology*
Swine / physiology*
Weaning
Zinc / chemistry,  pharmacology*
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Lipopolysaccharides; 0/Minerals; 0/Organometallic Compounds; 40816-51-1/zinc methionine; 63-68-3/Methionine; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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