| Supplementation of ascorbic acid prevents oxidative damages in arsenic-loaded hepatic tissue of rat: an ex vivo study. | |
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MedLine Citation:
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PMID: 20212062 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Oxidative stress due to arsenic toxicity and ameliorative potentiality of L-ascorbic acid was evaluated in an ex vivo system of rat hepatic tissue. The study revealed that arsenic increased the activity of superoxide dismutase (SOD) and catalase (CAT) and the level of lipid peroxidation (LPO), protein carbonyl (PC) and nitric oxide (NO) at 1 hour, 1.5 hours and 2 hours of incubation. Co-treatment with L-ascorbic acid was found effective to normalize the activity of SOD and CAT and the production of LPO, PC and NO in hepatic tissue. This ex vivo study suggested that ascorbic acid is helpful to ameliorate arsenic-induced oxidative stress. This may be one of the alternative screening systems to study the efficacy of antioxidant and hepatoprotective agent. |
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Authors:
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Tanmoy Rana; Asit Kumar Bera; Subhashree Das; Diganta Pan; Subhasish Bandyopadhyay; Debasis Bhattacharya; Sumanta De; Subrata Kumar Das |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-08 |
Journal Detail:
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Title: Human & experimental toxicology Volume: 29 ISSN: 1477-0903 ISO Abbreviation: Hum Exp Toxicol Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9004560 Medline TA: Hum Exp Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 965-72 Citation Subset: IM |
Affiliation:
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Indian Veterinary Research Institute, Kolkata, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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