| Supplementation of ascorbic acid and alpha-tocopherol is useful to preventing bone loss linked to oxidative stress in elderly. | |
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MedLine Citation:
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PMID: 20617290 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the effect of ascorbic acid and alpha-tocopherol on oxidative stress and bone mineral density (BMD) in elderly people. DESIGN: A double-blind, controlled clinical assay was carried out in a sample of 90 elderly subjects divided into three age-paired random groups with 30 subjects in each group. Group Tx0 received placebo, group Tx1 received 500 mg of ascorbic acid and 400 IU of alpha-tocopherol, whereas group Tx2 received 1,000 mg of ascorbic acid and 400 IU of alpha-tocopherol, for a 12-month period. MEASUREMENTS: We measured thiobarbituric acid reactive substances (TBARS), total antioxidant status (TAS), superoxide dismutase (SOD), and glutation peroxidase (GPx); BMD was obtained on DXA of hip and spine before and after the 12-month treatment period with supplementation of vitamins C and E. RESULTS: We found a positive correlation between hip-BMD and SOD (r = 0.298, p < 0.05) and GPx (r = 0.214, p < 0.05). Also, a significantly lower decrease of LPO (p < 0.05) was observed as linked with hip bone loss in the Tx2 group than in the Tx0 group. CONCLUSIONS: Our findings suggest that that administration of 1,000 mg of ascorbic acid together with 400 IU of alpha-tocopherol could be useful in preventing or aiding in the treatment of age-related osteoporosis. |
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Authors:
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M Ruiz-Ramos; L Alberto Vargas; T I Fortoul Van der Goes; A Cervantes-Sandoval; V M Mendoza-Nunez |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The journal of nutrition, health & aging Volume: 14 ISSN: 1760-4788 ISO Abbreviation: J Nutr Health Aging Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-09 Completed Date: 2010-10-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100893366 Medline TA: J Nutr Health Aging Country: France |
Other Details:
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Languages: eng Pagination: 467-72 Citation Subset: IM |
Affiliation:
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Unidad de Investigación en Gerontología, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, México DF, México. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antioxidants / pharmacology* Ascorbic Acid / pharmacology* Bone Density* / drug effects, physiology Dietary Supplements Double-Blind Method Female Glutathione Peroxidase / blood Humans Male Osteoporosis / prevention & control* Oxidative Stress / drug effects* Superoxide Dismutase / blood Thiobarbituric Acid Reactive Substances / metabolism alpha-Tocopherol / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Thiobarbituric Acid Reactive Substances; 50-81-7/Ascorbic Acid; 59-02-9/alpha-Tocopherol; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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