| Supplementary oxygen for emergency Caesarean section under regional anaesthesia. | |
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MedLine Citation:
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PMID: 19011261 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Controversy still exists if the administration of supplementary oxygen to patients having emergency Caesarean section (CS) under regional anaesthesia is beneficial or potentially harmful. Therefore, in a prospective double-blinded study, we randomized patients having emergency CS under regional anaesthesia to receive either air or 60% oxygen until delivery and compared the effects on fetal oxygenation and lipid-peroxidation in the mother and baby. METHODS: We recruited 131 women having emergency CS under regional anaesthesia. Either 21% (air group) or 60% oxygen (oxygen group) was administered using a Venturi-type facemask until delivery. We compared the oxygen exposure duration, umbilical arterial (UA) and venous (UV) blood gases and oxygen content, and plasma concentration of 8-isoprostane. Subanalysis was performed according to whether or not fetal compromise was considered present. RESULTS: Data from 125 patients were analysed. For the oxygen group vs the air group, there were greater values for UA PO(2) [mean 2.2 (SD 0.5) vs 1.9 (0.6) kPa, P=0.01], UA O(2) content [6.6 (2.5) vs 4.9 (2.8) ml dl(-1), P=0.006], UV PO(2) [3.8 (0.8) vs 3.2 (0.8) kPa, P<0.0001], and UV O(2) content [12.9 (3.5) vs 10.4 (3.8) ml dl(-1), P=0.001]. There was no difference between the groups in maternal, UA, or UV 8-isoprostane concentration. Apgar scores and UA pH were similar between the groups. Similar changes were observed regardless of whether fetal compromise was considered present (n=37) or not (n=88). CONCLUSIONS: Breathing 60% oxygen during emergency CS under regional anaesthesia increased fetal oxygenation with no associated increase in lipid-peroxidation in the mother or fetus. |
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Authors:
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K S Khaw; C C Wang; W D Ngan Kee; W H Tam; F F Ng; L A H Critchley; M S Rogers |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2008-11-16 |
Journal Detail:
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Title: British journal of anaesthesia Volume: 102 ISSN: 1471-6771 ISO Abbreviation: Br J Anaesth Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-08 Completed Date: 2009-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: England |
Other Details:
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Languages: eng Pagination: 90-6 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China. kimkhaw@cuhk.edu.hk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anesthesia, Conduction / methods* Anesthesia, Obstetrical / methods* Apgar Score Cesarean Section* Double-Blind Method Emergencies Female Fetal Blood / metabolism Humans Lipid Peroxidation Middle Aged Oxygen / blood Oxygen Inhalation Therapy* / adverse effects Oxyhemoglobins / metabolism Partial Pressure Pregnancy Prospective Studies Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Oxyhemoglobins; 7782-44-7/Oxygen |
| Comments/Corrections | |
Comment In:
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Br J Anaesth. 2009 Jan;102(1):1-2
[PMID:
19059918
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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