Document Detail

Supplementary ultrafiltration may improve inflammation and cardiac dysfunction in patients with high interdialytic weight gain.
MedLine Citation:
PMID:  22922813     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: We tested the hypothesis that adding an ultrafiltration session per week may improve brain natriuretic peptide (BNP) and C-reactive protein (CRP) levels and left ventricular function in hypervolemic hemodialysis patients.
METHODS: Twenty-six patients (18 male, 8 female; mean age 57.2 ± 12.7 years) who had high BNP and CRP levels and interdialytic weight gain (IDWG) were recruited for the study. Patients were randomly allocated to one of two groups, namely the supplementary ultrafiltration (sUF) group (n = 13), who had additional ultrafiltrations for 8 weeks, and the regular hemodialysis (rHD) group (n = 13), who continued regular dialysis treatments.
RESULTS: There were significant decreases in mean CRP and BNP levels and mean arterial blood pressure and significant improvements in left ventricular function in the sUF group, with no changes in the rHD group. Higher IDWG was observed in the rHD group compared to the sUF group after 8 weeks.
CONCLUSION: sUF may be effective in reducing inflammatory burden and improving cardiac function.
Rahmi Yilmaz; Mustafa Arici; Tolga Yildirim; Levent Sahiner; Kudret Aytemir; Bulent Altun; Yunus Erdem; Cetin Turgan
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-08-24
Journal Detail:
Title:  Blood purification     Volume:  34     ISSN:  1421-9735     ISO Abbreviation:  Blood Purif.     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-18     Completed Date:  2013-06-10     Revised Date:  2013-07-26    
Medline Journal Info:
Nlm Unique ID:  8402040     Medline TA:  Blood Purif     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  67-74     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Department of Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey. ryilmaz @
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MeSH Terms
C-Reactive Protein / metabolism
Inflammation / metabolism*
Middle Aged
Natriuretic Peptide, Brain / blood
Renal Dialysis / adverse effects*
Ventricular Dysfunction, Left / etiology*,  metabolism*
Weight Gain*
Reg. No./Substance:
114471-18-0/Natriuretic Peptide, Brain; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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