Document Detail

Supplemental oxygen and sleep at altitude.
MedLine Citation:
PMID:  17173516     Owner:  NLM     Status:  MEDLINE    
Windsor, Jeremy S., and George W. Rodway. Supplemental oxygen and sleep at altitude. High Alt. Med. Biol. 7:307-311, 2006.--The purpose of this study was to examine the effect supplemental oxygen has on the respiratory and cardiovascular system of a mountaineer during sleep at high altitude by using a novel ambulatory, multisensor, continuous monitoring device. Supplemental oxygen was administered to a healthy subject via a nasal demand system (0, 16.7, 33.3, or 50 mL/sec per pulse dose delivered over 1 sec) during the first three nights of sleep at 4900 and 5700 m. Increases in pulse dose resulted in a consistent rise in Sa(O(2)) and a fall in minute ventilation (p < 0.05). The 50-mL pulse dose resulted in the greatest changes, with an increase in Sa(O(2)) from 68.5% to 81% (p < 0.05) and a fall in minute ventilation from 13.1 to 10.9 L/min (p < 0.05) being noted. Changes in Sa(O(2)) and minute ventilation also coincided with a fall in apnea/hypopnea index (AHI). At 4900 m the AHI fell from 12.5-52.3 (breathing air) to 0-7.5 (50-mL oxygen pulse), whereas at 5700 m a decrease from 49.1-80.4 to 3.5-10.0 was observed. No changes in respiratory rate or heart rate were identified when different pulse doses were compared (p < 0.05). The multisensor monitoring device proved to be a highly effective system, demonstrating marked improvements in Sa(O(2)), tidal volume, and AHI in our participant when supplemental oxygen was administered via a nasal demand system.
Jeremy S Windsor; George W Rodway
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  High altitude medicine & biology     Volume:  7     ISSN:  1527-0297     ISO Abbreviation:  High Alt. Med. Biol.     Publication Date:  2006  
Date Detail:
Created Date:  2006-12-18     Completed Date:  2007-03-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100901183     Medline TA:  High Alt Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  307-11     Citation Subset:  IM; S    
Centre for Aviation, Space and Extreme Environment Medicine, University College London.
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MeSH Terms
Administration, Intranasal
Continuous Positive Airway Pressure / methods*
Heart Rate
Oxygen / administration & dosage*
Respiratory Physiological Phenomena*
Sleep / physiology*
Reg. No./Substance:

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