Document Detail


Supplemental oxygen and hyperbaric treatment at high altitude: cardiac and respiratory response.
MedLine Citation:
PMID:  17571664     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: The most effective treatment for high altitude sickness is prompt descent. However, rapid descent is sometimes impossible and alternative solutions are desirable. Supplemental oxygen at ambient pressure and hyperbaric oxygen in a hyperbaric tent have both been demonstrated to improve symptoms and increase arterial oxygenation (SaO2) in those with high altitude sickness; however, their use in combination has not previously been described in a controlled study. METHODS AND RESULTS: In this feasibility study, the SaO2 of six healthy, well-acclimatized participants rose from 76.5 to 97.5% at 4900 m and 72.5 to 96.0% at 5700 m following the administration of oxygen via a nasal demand circuit (33 ml of oxygen per pulse) inside a hyperbaric tent (107 mmHg above ambient barometric pressure) (p < 0.05). This contrasted with an increase in SaO2 to 89.5% at 4900 m and 86.3% at 5700 m with only supplemental oxygen and an increase in SaO2 to 92.8% (4900 m) and 90.5% (5700 m) with only hyperbaric exposure. In addition, combining treatments also resulted in an increase in tidal volume (29.0 and 31.0%) and minute ventilation (12.0 and 23.0%) together with a fall in heart rate (15.0 and 17.0%) at 4900 and 5700 m, respectively. No significant differences in heart rate, tidal volume, minute ventilation, SaO2, or respiratory rate were seen when hyperbaric treatment and supplemental oxygen were directly compared. CONCLUSIONS: In healthy, well-acclimatized subjects the combination of hyperbaric exposure and supplemental oxygen has a noteworthy effect on physiological parameters at high altitude. Awareness of this knowledge may enhance the treatment of patients with life-threatening high altitude sickness.
Authors:
George W Rodway; Jeremy S Windsor; Nigel D Hart;
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  78     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-18     Completed Date:  2007-07-24     Revised Date:  2008-03-18    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  613-7     Citation Subset:  IM; S    
Affiliation:
Center for Sleep and Respiratory Neurobiology, University of Pennsylvania Schools of Medicine and Nursing, 420 Guardian Drive, Philadelphia, PA 19104-6096, USA. gwrodway@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Altitude Sickness / therapy*
Blood Gas Analysis
Equipment and Supplies
Humans
Hyperbaric Oxygenation / instrumentation,  methods*
Male
Mountaineering / physiology*
Oxygen / metabolism*
Respiratory Function Tests
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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