| Supplemental dietary racemic equol has modest benefits to bone but has mild uterotropic activity in ovariectomized rats. | |
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MedLine Citation:
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PMID: 19710157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Soy isoflavones and their metabolites, with estrogenic activity, have been considered candidates for reducing postmenopausal bone loss. In this study, we examined the effect of dietary equol, a bioactive metabolite of the soy isoflavone daidzein, on equol tissue distribution, bone parameters, and reproductive tissue activity using an adult ovariectomized (OVX) rat model. An 8-wk feeding study was conducted to compare 4 dietary treatments of equol (0, 50, 100, 200 mg/kg diet) in 6-mo-old OVX female Sprague-Dawley rats. A dose response increase in tissue equol concentrations was observed for serum, liver, kidney, and heart, and a plateau occurred at 100 mg equol/kg diet for intestine. In OVX rats receiving 200 mg equol/kg diet, femoral calcium concentration was greater than those receiving lower doses but was still less than SHAM (P < 0.05), and other bone measures were not improved. Tibia calcium concentrations were lower in OVX rats receiving 100 and 200 mg equol/kg diet compared with the OVX control rats. Trabecular bone mineral density of tibia was also lower in equol-fed OVX rats. At this dietary equol intake, uterine weight was higher (P < 0.05) than in other OVX groups but lower than the SHAM-operated intact rats. The 200 mg/kg diet dose of dietary equol significantly increased proliferative index in the uterine epithelium. Dietary equol had no stimulatory effect on mammary gland epithelium. We conclude that in OVX rats, a dietary equol dose that had modest effect on bone also exerts mild uterotropic effects. |
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Authors:
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Leecole L Legette; Berdine R Martin; Mohammad Shahnazari; Wang-Hee Lee; William G Helferich; Junqi Qian; David J Waters; Alireza Arabshahi; Stephen Barnes; Jo Welch; David G Bostwick; Connie M Weaver |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-08-26 |
Journal Detail:
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Title: The Journal of nutrition Volume: 139 ISSN: 1541-6100 ISO Abbreviation: J. Nutr. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-21 Completed Date: 2009-10-06 Revised Date: 2010-10-04 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1908-13 Citation Subset: IM |
Affiliation:
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Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Density / drug effects* Bone and Bones / chemistry Calcium / analysis Dietary Supplements* Female Isoflavones / pharmacology* Lethal Dose 50 Organ Size Ovariectomy Phytoestrogens / pharmacology* Rats Rats, Sprague-Dawley Uterus / anatomy & histology, drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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P50 AT000477-07S1/AT/NCCAM NIH HHS; P50 AT00477-01/AT/NCCAM NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Isoflavones; 0/Phytoestrogens; 531-95-3/equol; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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