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Supplemental dietary leucine and the skeletal muscle anabolic response to essential amino acids.
MedLine Citation:
PMID:  21884134     Owner:  NLM     Status:  In-Data-Review    
Skeletal muscle protein synthesis (MPS) is regulated by a number of dietary factors, to include essential amino acids (EAAs). Leucine, a branched-chain amino acid, has been identified as a stimulator of MPS in many cell culture and animal studies. However, whether supplemental leucine exerts a unique stimulatory effect, as compared to other EAAs, on muscle anabolism in humans has not been clearly demonstrated. A recent study found no improvement in resting MPS in adults who consumed a 10 g EAA supplement providing added leucine (3.5 g leucine) when compared to a control 10 g EAA supplement (1.8 g leucine). These findings suggest that added leucine is unnecessary for the stimulation of MPS when sufficient EAAs are provided; however, the study of supplemental leucine during conditions such as endurance exercise, caloric deprivation, and ageing may be warranted.
Stefan M Pasiakos; James P McClung
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrition reviews     Volume:  69     ISSN:  1753-4887     ISO Abbreviation:  Nutr. Rev.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376405     Medline TA:  Nutr Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  550-7     Citation Subset:  IM    
Copyright Information:
© 2011 International Life Sciences Institute.
SM Pasiakos and JP McClung are with the Military Nutrition Division, US Army Research Institute of Environmental Medicine (USARIEM), Natick, Massachusetts, USA.
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