| Supplemental dietary leucine and the skeletal muscle anabolic response to essential amino acids. | |
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MedLine Citation:
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PMID: 21884134 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Skeletal muscle protein synthesis (MPS) is regulated by a number of dietary factors, to include essential amino acids (EAAs). Leucine, a branched-chain amino acid, has been identified as a stimulator of MPS in many cell culture and animal studies. However, whether supplemental leucine exerts a unique stimulatory effect, as compared to other EAAs, on muscle anabolism in humans has not been clearly demonstrated. A recent study found no improvement in resting MPS in adults who consumed a 10 g EAA supplement providing added leucine (3.5 g leucine) when compared to a control 10 g EAA supplement (1.8 g leucine). These findings suggest that added leucine is unnecessary for the stimulation of MPS when sufficient EAAs are provided; however, the study of supplemental leucine during conditions such as endurance exercise, caloric deprivation, and ageing may be warranted. |
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Authors:
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Stefan M Pasiakos; James P McClung |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nutrition reviews Volume: 69 ISSN: 1753-4887 ISO Abbreviation: Nutr. Rev. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376405 Medline TA: Nutr Rev Country: United States |
Other Details:
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Languages: eng Pagination: 550-7 Citation Subset: IM |
Copyright Information:
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© 2011 International Life Sciences Institute. |
Affiliation:
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SM Pasiakos and JP McClung are with the Military Nutrition Division, US Army Research Institute of Environmental Medicine (USARIEM), Natick, Massachusetts, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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