| Overview of the changing epidemiology of candidemia. | |
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MedLine Citation:
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PMID: 19519284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Candida spp. are currently the fourth most common cause of bloodstream infections in US hospitals, and the third most common cause of bloodstream infections in the intensive care unit. Over the last 2 decades there has been a shift towards a greater involvement of non-Candida albicans spp. as the cause of candidemia. Several of these non-albicans spp. (e.g., C. glabrata and C. krusei ) exhibit resistance to traditional triazole antifungals like fluconazole, and cross-resistance with newer triazoles, focusing attention on the first-line use of antifungals such as the echinocandins, which possess improved activity against fluconazole-resistant strains. Recent treatment guidelines from the Infectious Diseases Society of America (IDSA) recommend an echinocandin as primary therapy for nonneutropenic or neutropenic patients with moderately severe to severe candidiasis and for patients at risk for infection with a triazole-resistant strain. However, further improvement in candidemia-associated mortality will only be attainable with the development and validation of new diagnostic tools that will allow earlier detection, discrimination, and treatment of invasive candidiasis. Clinicians should remain vigilant to wider emergence of Candida spp. with echinocandin resistance. |
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Authors:
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Russell E Lewis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current medical research and opinion Volume: 25 ISSN: 1473-4877 ISO Abbreviation: Curr Med Res Opin Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-24 Completed Date: 2009-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0351014 Medline TA: Curr Med Res Opin Country: England |
Other Details:
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Languages: eng Pagination: 1732-40 Citation Subset: IM |
Affiliation:
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Department of Clinical Sciences and Administration, University of Houston College of Pharmacy, Houston, TX, USA. rlewis@uh.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aspergillosis
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mortality Candidiasis / drug therapy, epidemiology*, etiology, mortality Drug Resistance, Fungal / physiology Forecasting Humans Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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