Document Detail

Superwarfarin intoxication: hematuria is a major clinical manifestation.
MedLine Citation:
PMID:  19588218     Owner:  NLM     Status:  MEDLINE    
Since superwarfarin is popular and readily available in stores, it may cause intoxication or overexposure, which can result in coagulopathy or abnormal bleeding in humans and, thus, is an important public health problem. We report our clinical experience with superwarfarin intoxication. Nine patients, including eight patients who had histories of ingesting superwarfarin, were studied. Of the patients, hematuria occurred in eight. Laboratory tests among the nine patients showed extremely prolonged prothrombin times and activated partial thromboplastin times, which could be corrected to normal by mixing 1:1 with normal pooled plasma; they also had very low functional levels of factor II, VII, IX, X, and proteins C and S, but normal functional levels of factors V, VIII, fibrinogen, and anti-thrombin III. Large doses of vitamin K1 were needed for 3 months or more to treat and correct the coagulopathy among the patients. The majority of the patients presented with gross hematuria, suggesting that hematuria is probably a major clinical manifestation of superwarfarin intoxication. Prolonged use of large doses of vitamin K1 is needed for the treatment of superwarfarin intoxication.
Yi-Feng Wu; Cheng-Shyong Chang; Chih-Yuan Chung; Hsuan-Yu Lin; Chuan-Cheng Wang; Ming-Ching Shen
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-09
Journal Detail:
Title:  International journal of hematology     Volume:  90     ISSN:  1865-3774     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-24     Completed Date:  2009-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  170-3     Citation Subset:  IM    
Section of Hemato-Oncology, Department of Internal Medicine, Changhua Christian Hospital, No. 135 Nansiao Street, Changhua City 500, Changhua County, Taiwan.
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MeSH Terms
4-Hydroxycoumarins / poisoning*
Blood Coagulation Tests
Hematuria / blood,  chemically induced*,  drug therapy
Middle Aged
Rodenticides / poisoning*
Suicide, Attempted*
Vitamin K 1 / therapeutic use
Vitamins / therapeutic use
Young Adult
Reg. No./Substance:
0/4-Hydroxycoumarins; 0/Rodenticides; 0/Vitamins; 56073-10-0/bromfenacoum; 84-80-0/Vitamin K 1

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