Document Detail

Supervised exercise training combined with ginkgo biloba treatment for patients with peripheral arterial disease.
MedLine Citation:
PMID:  17702699     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate whether a combination of supervised exercise training and ginkgo biloba treatment is a better treatment than exercise training alone for patients with peripheral arterial disease. DESIGN: A 24-week double-blind, placebo-controlled ginkgo biloba trial with the first 12-week period as a non-exercise control stage and the second 12-week period as an exercise training stage. SETTING: Exercise physiology laboratory. SUBJECTS: Twenty-two subjects with peripheral arterial disease. INTERVENTIONS: The subjects were randomly allocated into a ginkgo or a placebo group. During the first stage, the ginkgo group ingested standardized ginkgo biloba tablets with a daily dosage of 240 mg, while the placebo group received placebo tablets. During the second stage, all subjects engaged in a supervised treadmill-walking programme while continuing to take the same dosage of ginkgo biloba or placebo tablets. MAIN MEASURES: Walking capacity on treadmill, oxygen consumption during exercise, peripheral haemodynamics and blood viscosity were measured at baseline, and after the first and the second stages of treatment. RESULTS: The ginkgo group did not show significant changes in most of the measured variables after each stage of treatment, except that the maximal walking time was significantly increased after the combined treatment (from 236 +/- 112 seconds to 557 +/- 130 seconds, P < 0.001). However, similar response was also found in the placebo group after exercise training (from 384 +/- 125 seconds to 820 +/- 146 seconds, P < 0.001). CONCLUSION: Supervised exercise training combined with ginkgo biloba treatment did not produce greater beneficial effects than exercise training alone in patients with peripheral arterial disease.
Jianxiong Wang; Shi Zhou; Roger Bronks; John Graham; Stephen Myers
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical rehabilitation     Volume:  21     ISSN:  0269-2155     ISO Abbreviation:  Clin Rehabil     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-08-17     Completed Date:  2007-10-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802181     Medline TA:  Clin Rehabil     Country:  England    
Other Details:
Languages:  eng     Pagination:  579-86     Citation Subset:  IM    
Southern Cross University, Lismore, Australia.
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MeSH Terms
Combined Modality Therapy
Double-Blind Method
Exercise Therapy*
Ginkgo biloba*
Intermittent Claudication / drug therapy
Middle Aged
Peripheral Vascular Diseases / drug therapy*
Plant Extracts / therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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