Document Detail


Supertasting and PROP bitterness depends on more than the TAS2R38 gene.
MedLine Citation:
PMID:  18209019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Polymorphisms in the TAS2R38 gene provide insight to phenotypes long associated 6-n-propylthiouracil (PROP) and phenylthiocarbamide bitterness. We tested relationships between TAS2R38 genotype, taste phenotype, and fungiform papillae (FP) number in 139 females and 59 males (age range 21-60 years), primarily of European ancestry. DNA was analyzed for 3 polymorphic sites, identifying common (alanine-valine-isoleucine [AVI/AVI], heterozygotes, proline-alanine-valine [PAV/PAV]) and rare (proline-valine-isoleucine, alanine-alanine-valine, AAI) forms. Individuals with PROP threshold >0.15 mM were almost exclusively AVI/AVI; those with threshold <0.1 mM could have any genotype. PAV/PAVs were more difficult to identify with PROP taste measures, although perceived bitterness of moderate PROP concentrations (0.32, 1 mM) had better correspondence with genotype than did threshold. For AVI/AVIs, increases in bitterness from 1 to 3.2 mM PROP nearly paralleled those of TAS2R38 heterozygotes and PAV/PAVs. Some bitterness gains were related to FP number sampled from a standard area on the tongue tip, yet the PROP bitterness-FP relationship differed across genotype. Among homozygotes, FP was a significant determinant of PROP bitterness; heterozygotes showed a flat relationship. Those tasting concentrated PROP as more bitter also tasted concentrated sucrose, citric acid, sodium chloride, and quinine as more intense, even after statistically controlling for TAS2R38 genotype, FP, and intensity of tones (nonoral standard). To summarize, although PROP threshold generally exhibited single-gene complete dominance, PROP bitterness may involve additional bitter receptors as evidenced by misclassification of some nontaster homozygotes and the bitterness functions for concentrated PROP. Variability in receptor expression may explain attenuated bitterness-FP relationships. PROP bitterness does associate with heightened taste sensations (i.e., supertasting), but this is not due to TAS2R38 polymorphisms.
Authors:
John E Hayes; Linda M Bartoshuk; Judith R Kidd; Valerie B Duffy
Related Documents :
18967329 - Pulse injection analysis with chemiluminescence detection: determination of citric acid...
17120089 - Changes in primary metabolism leading to citric acid overflow in aspergillus niger.
18468889 - Solubilization of morocco phosphorite by aspergillus niger.
16668249 - Mechanism of aluminum tolerance in snapbeans : root exudation of citric acid.
8148619 - Structure of acinetoferrin, a new citrate-based dihydroxamate siderophore from acinetob...
1914499 - Preventive effect of isocitrate on glucocorticoid-induced cataract formation of develop...
1581019 - Diurnal rhythms in rat brain large neutral amino acids (lnaas), monoamines and monoamin...
3421959 - Carrier-mediated uptake of cephalexin in human intestinal cells.
18164319 - Non-steroidal anti-inflammatory drugs have potent anti-fibrillogenic and fibril-destabi...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-01-21
Journal Detail:
Title:  Chemical senses     Volume:  33     ISSN:  0379-864X     ISO Abbreviation:  Chem. Senses     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-12     Completed Date:  2008-06-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8217190     Medline TA:  Chem Senses     Country:  England    
Other Details:
Languages:  eng     Pagination:  255-65     Citation Subset:  IM    
Affiliation:
Department of Nutritional Sciences, College of Agriculture and Natural Resources, University of Connecticut, Storrs, CT 06269-2101, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Amino Acid Substitution
Female
Gene Frequency
Genotype
Haplotypes
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide*
Propylthiouracil / chemistry*
Quinine / chemistry
Receptors, G-Protein-Coupled / genetics*
Taste / genetics*,  physiology
Taste Buds / anatomy & histology,  metabolism
Taste Threshold
Tongue / anatomy & histology,  metabolism
Grant Support
ID/Acronym/Agency:
AA09379/AA/NIAAA NIH HHS; DC00283/DC/NIDCD NIH HHS; GM57672/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, G-Protein-Coupled; 0/taste receptors, type 2; 130-95-0/Quinine; 51-52-5/Propylthiouracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Differential expression of SNMP-1 and SNMP-2 proteins in pheromone-sensitive hairs of moths.
Next Document:  Role salience and anticipated work--family relations among young adults with and without hearing los...