| Supersensitivity of quinpirole-evoked GTPase activation without changes in gene expression of D2 and Gi protein in the striatum of hemi-dopaminergic lesioned rats. | |
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MedLine Citation:
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PMID: 7970188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Quinpirole with D2 agonist activity showed a two-fold increase in the GTPase activity in the 6-hydroxydopamine-lesioned side of the striatum, compared with that in the control side. However, neither qualitative nor quantitative changes were observed in the gene expression of two alternative splicing products derived from dopamine D2 receptor gene or of Gil alpha, in the RNAase protection assay. These results suggest that D2 receptor-mediated supersensitization does not come from the D2 receptor upregulation. |
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Authors:
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A Inoue; H Ueda; Y Nakata; Y Misu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 175 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1994 Jul |
Date Detail:
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Created Date: 1994-12-29 Completed Date: 1994-12-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 107-10 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Yokohama City University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Cell Membrane / metabolism Corpus Striatum / drug effects, metabolism, physiology* DNA Primers Dopamine / physiology Dopamine Agonists / pharmacology* Dose-Response Relationship, Drug Enzyme Activation Ergolines / pharmacology* GTP Phosphohydrolases / metabolism* GTP-Binding Proteins / biosynthesis* Gene Expression* Male Molecular Sequence Data Polymerase Chain Reaction Quinpirole Rats Rats, Sprague-Dawley Receptors, Dopamine D2 / biosynthesis* Reference Values Sulpiride / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/Dopamine Agonists; 0/Ergolines; 0/Receptors, Dopamine D2; 15676-16-1/Sulpiride; 85760-74-3/Quinpirole; EC 3.6.1.-/GTP Phosphohydrolases; EC 3.6.1.-/GTP-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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