| Superselective ophthalmic artery fibrinolytic therapy for the treatment of central retinal vein occlusion. | |
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MedLine Citation:
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PMID: 11090479 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To study the effect of superselective ophthalmic artery fibrinolysis as a treatment for central retinal vein occlusion (CRVO). METHODS: Retrospective, university based single centre study. The charts of 26 eyes of 26 patients treated were reviewed. Among the 26 patients, there were nine cases of combined artery and vein occlusion, three cases of combined cilioretinal artery and CRVO, and 14 cases of classic CRVO. Complete preoperative and postoperative ophthalmological examination and fluorescein angiography were performed in all cases. The therapeutic procedure comprised the infusion of urokinase through a microcatheter into the ostium of the ophthalmic artery, via a femoral artery approach. The main outcome measure was the improvement in visual acuity 48 hours after the procedure. RESULTS: Six eyes of six patients exhibited significant improvement in visual acuity immediately after the fibrinolysis procedure. Among them, four had a initial funduscopic appearance suggestive of combined occlusion of the central retinal artery (CRAO) and vein. For these patients, the visual benefit was maintained in the long term. Intravitreal haemorrhage occurred in two patients. There were no extraocular complications linked to the procedure. CONCLUSIONS: Selective ophthalmic artery infusion of urokinase was followed by improvement in VA in six out of 26 cases of CRVO. Eyes with combined CRAO and CRVO with recent visual loss appeared to be the most responsive. This treatment did not prevent the occurrence of ischaemia in the failure cases. The efficacy of in situ fibrinolysis for treatment of CRVO needs to be further evaluated in a controlled study. |
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Authors:
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M Paques; J N Vallée; D Herbreteau; A Aymart; P Y Santiago; F Campinchi-Tardy; D Payen; J J Merlan; A Gaudric; P Massin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The British journal of ophthalmology Volume: 84 ISSN: 0007-1161 ISO Abbreviation: Br J Ophthalmol Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2000-12-13 Completed Date: 2001-01-04 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0421041 Medline TA: Br J Ophthalmol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1387-91 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Hôpital Lariboisière, Université Paris 7, Paris, France. michel.paques@lrb.ap-hop-paris.fr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Female Fundus Oculi Humans Infusions, Intra-Arterial Male Middle Aged Ophthalmic Artery Pilot Projects Plasminogen Activators / administration & dosage, therapeutic use* Retinal Artery Occlusion / drug therapy Retinal Vein Occlusion / drug therapy* Retrospective Studies Thrombolytic Therapy / methods* Treatment Outcome Urokinase-Type Plasminogen Activator / administration & dosage, therapeutic use* Visual Acuity / drug effects |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.-/Plasminogen Activators; EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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