| Superselective intra-arterial infusion of papaverine for the treatment of cerebral vasospasm after subarachnoid hemorrhage. | |
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MedLine Citation:
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PMID: 1432124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This report describes the successful treatment of cerebral vasospasm after subarachnoid hemorrhage with superselective intra-arterial infusion of papaverine hydrochloride. Thirty-seven vascular territories in 10 patients with symptomatic vasospasm were treated according to the following protocol. Percutaneous transluminal angioplasty was performed in two steps. First, a silicone balloon was used for dilation of the internal carotid artery and the proximal portions of the middle cerebral artery. A silicone leak balloon or Tracker-18 catheter was then introduced into or just proximal to the site of vasospasm not accessible to the angioplasty balloon catheter for superselective infusion of 0.2% papaverine. Thirty-four of 37 vascular territories were successfully dilated, and eight of 10 patients showed improvement in neurological function after the procedure. There were no serious side effects due to infusion of papaverine. It is essential to infuse the papaverine just proximal to the spastic vessels in order to deliver sufficient concentration of drug, and infusion should be carried out as early as possible before the artery loses its ability to return to a normal luminal size. Superselective intraarterial infusion of papaverine is an alternative method of treatment for symptomatic vasospasm. |
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Authors:
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Y Kaku; Y Yonekawa; T Tsukahara; K Kazekawa |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of neurosurgery Volume: 77 ISSN: 0022-3085 ISO Abbreviation: J. Neurosurg. Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1992-12-17 Completed Date: 1992-12-17 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0253357 Medline TA: J Neurosurg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 842-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurosurgery, National Cardiovascular Center, Osaka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Aneurysm, Ruptured / complications Angioplasty, Balloon Female Humans Infusions, Intra-Arterial Intracranial Aneurysm / complications Ischemic Attack, Transient / drug therapy*, etiology, radiography Male Middle Aged Nicardipine / administration & dosage Papaverine / administration & dosage* Rupture, Spontaneous Subarachnoid Hemorrhage / complications* Urokinase-Type Plasminogen Activator / administration & dosage |
| Chemical | |
Reg. No./Substance:
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55985-32-5/Nicardipine; 58-74-2/Papaverine; EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
| Comments/Corrections | |
Comment In:
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J Neurosurg. 1993 Nov;79(5):797-8
[PMID:
8410265
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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