Document Detail

Superselective intra-arterial chemotherapy for advanced maxillary sinus cancer: an evaluation of arterial perfusion with computed tomographic arteriography and of tumor response.
MedLine Citation:
PMID:  18520544     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of our study was to elucidate the relationship between arterial perfusion in advanced maxillary sinus cancer which was opacified by superselective intra-arterial computed tomographic arteriography (IA-CTA) and the tumor response to intra-arterial chemotherapy. METHODS: Superselective IA-CTA was performed to identify the feeding arteries and their perfusion in advanced maxillary sinus cancer in 10 patients. Cisplatin was selectively infused into these feeding arteries, except for the internal carotid artery. RESULTS: The results were assessed in 9 of the 10 patients, and a complete response was achieved in 5 patients in whom either the entire tumor, or most of the tumor, was perfused by the branches of the external carotid artery. In 4 patients with a partial response, the residual tumors were seen in the territory of the perfusion defect or in the perfusion territory of the internal carotid artery. CONCLUSION: Superselective IA-CTA is a useful technique to correctly identify the intratumoral perfusion and to predict tumor response to the intra-arterial chemotherapy of advanced maxillary sinus cancer.
Etsushi Iida; Munemasa Okada; Toshifumi Mita; Matakazu Furukawa; Katsuyoshi Ito; Naofumi Matsunaga
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of computer assisted tomography     Volume:  32     ISSN:  0363-8715     ISO Abbreviation:  J Comput Assist Tomogr     Publication Date:    2008 May-Jun
Date Detail:
Created Date:  2008-06-03     Completed Date:  2008-06-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703942     Medline TA:  J Comput Assist Tomogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  397-402     Citation Subset:  IM    
Department of Radiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami Kogushi, Ube, Yamaguchi, Japan.
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MeSH Terms
Antineoplastic Agents / administration & dosage*
Carotid Arteries
Cisplatin / administration & dosage
Injections, Intra-Arterial
Maxillary Sinus Neoplasms / blood supply,  drug therapy*,  radiography*
Middle Aged
Tomography, X-Ray Computed / methods*
Treatment Outcome
Reg. No./Substance:
0/Antineoplastic Agents; 15663-27-1/Cisplatin

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